SCHEMBL9339154

SCHEMBL9339154

CCCCc1cccc(=O)n1Cc1ccc(-c2ccccc2N)cc1

nearest known ligand 0.64

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AGTR1 P30556 6/20 0.46
AGTR2 P50052 4/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9339121 0.83 TLR7 (0.43) AGTR1AGTR2
SCHEMBL9532259 0.83 AGTR1 (0.67) AGTR1AGTR2
SCHEMBL9337497 0.83 PPARG (0.56) AGTR1AGTR2
SCHEMBL9341188 0.82 AGTR1 (0.43) AGTR1AGTR2
SCHEMBL9533553 0.80 AGTR1 (0.55) AGTR1AGTR2
SCHEMBL9337412 0.80 PPARG (0.55) AGTR1AGTR2
SCHEMBL9337763 0.79 AGTR1 (0.51) AGTR1AGTR2
SCHEMBL9337539 0.78 PDE4A (0.39) AGTR1AGTR2
SCHEMBL9336977 0.78 ESR1 (0.42) AGTR1AGTR2
Potassium SCHEMBL9535277 0.78 AGTR1 (0.50) AGTR1AGTR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5332750-A Treatment of hypertension, aldosteronism, cardiac insufficienc y MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1994-07-26 US disclosed