SCHEMBL9532259

SCHEMBL9532259

CCCCc1cccc(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1

nearest known ligand 0.69

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AGTR1 P30556 7/20 0.67
AGTR2 P50052 5/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9533553 0.88 AGTR1 (0.55) AGTR1AGTR2
SCHEMBL9531652 0.87 AGTR1 (0.67) AGTR1AGTR2
SCHEMBL9535397 0.86 AGTR1 (0.70) AGTR1AGTR2
SCHEMBL8884290 0.86 AGTR1 (0.70) AGTR1AGTR2
SCHEMBL9531497 0.84 AGTR1 (0.66) AGTR1AGTR2
SCHEMBL9532603 0.83 AGTR1 (0.66) AGTR1AGTR2
SCHEMBL9037696 0.83 AGTR1 (0.63) AGTR1AGTR2
SCHEMBL9035766 0.83 AGTR1 (0.66) AGTR1AGTR2
SCHEMBL9339154 0.83 AGTR1 (0.46) AGTR1AGTR2
SCHEMBL9339096 0.82 AGTR1 (0.54) AGTR1AGTR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0572455-A1 SUBSTITUTED PYRIDINONES AND PYRIMIDINONES AS ANGIOTENSIN II ANTAGONISTS Astra Pharmaceuticals Limited (GB) 1993-12-08 EP claimed
WO-1992014714-A1 SUBSTITUTED PYRIDINONES AND PYRIMIDINONES AS ANGIOTENSIN II ANTAGONISTS FISONS PLC (GB) 1992-09-03 WO claimed
EP-0500297-A1 Substituted pyridinones and pyrimidinones as angiotensin II antagonists FISONS plc (GB) 1992-08-26 EP claimed
EP-0572455-A1 SUBSTITUTED PYRIDINONES AND PYRIMIDINONES AS ANGIOTENSIN II ANTAGONISTS Astra Pharmaceuticals Limited (GB) 1993-12-08 EP disclosed
EP-0539591-A1 BENZODIAZEPINE DERIVATIVES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1993-05-05 EP disclosed
WO-1992014714-A1 SUBSTITUTED PYRIDINONES AND PYRIMIDINONES AS ANGIOTENSIN II ANTAGONISTS FISONS PLC (GB) 1992-09-03 WO disclosed
EP-0500297-A1 Substituted pyridinones and pyrimidinones as angiotensin II antagonists FISONS plc (GB) 1992-08-26 EP disclosed
WO-1992001683-A1 BENZODIAZEPINE DERIVATIVES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1992-02-06 WO disclosed