Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 8/20 | 0.54 |
| ▸ | GART | P22102 | 1/20 | 0.49 |
| ▸ | ATIC | P31939 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | TYMS | P04818 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9339157 | 1.00 | DHFR (0.54) | DHFRGARTATICKDM4EALDH1A1 | |
| SCHEMBL9339174 | 0.99 | DHFR (0.54) | DHFRGARTATICKDM4EALDH1A1 | |
| SCHEMBL9339172 | 0.99 | DHFR (0.54) | DHFRGARTATICKDM4EALDH1A1 | |
| SCHEMBL9343679 | 0.98 | DHFR (0.54) | DHFRGARTATICKDM4EALDH1A1 | |
| SCHEMBL9343678 | 0.98 | DHFR (0.54) | DHFRGARTATICKDM4EALDH1A1 | |
| SCHEMBL9037720 | 0.89 | DHFR (0.54) | DHFRGARTATICKDM4EALDH1A1 | |
| SCHEMBL8997169 | 0.84 | DHFR (0.50) | DHFRGARTATICKDM4EALDH1A1 | |
| SCHEMBL8997185 | 0.84 | DHFR (0.50) | DHFRGARTATICKDM4EALDH1A1 | |
| SCHEMBL9038286 | 0.84 | DHFR (0.68) | DHFRKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL9446073 | 0.83 | DHFR (0.59) | DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0325343-B1 | L-glutamic acid derivatives | UNIV PRINCETON (US) | 1994-06-22 | — | — | EP | disclosed |
| US-4871743-A | L-glutamic acid derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1989-10-03 | — | — | US | disclosed |
| EP-0325343-A2 | L-glutamic acid derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1989-07-26 | — | — | EP | disclosed |