Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | CA1 | P00915 | 3/20 | 0.52 |
| ▸ | CA2 | P00918 | 3/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.51 |
| ▸ | CA12 | O43570 | 2/20 | 0.51 |
| ▸ | CA9 | Q16790 | 2/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.51 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.51 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.51 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11300545 | 0.88 | KMT2A (0.61) | KMT2AMEN1ALDH1A1POLBCA1 | |
| SCHEMBL27291385 | 0.86 | ALDH1A1 (0.77) | ALDH1A1POLBHDAC6HDAC8HDAC3 | |
| SCHEMBL14254926 | 0.85 | HDAC6 (0.69) | KMT2AMEN1HDAC6HDAC8HDAC3 | |
| SCHEMBL1833186 | 0.85 | HDAC6 (0.69) | KMT2AMEN1HDAC6HDAC8HDAC3 | |
| SCHEMBL11668868 | 0.80 | ALDH1A1 (0.68) | KMT2AMEN1ALDH1A1POLBHDAC6 | |
| SCHEMBL10598594 | 0.78 | POLB (0.66) | ALDH1A1POLBCA1CA2 | |
| SCHEMBL27534025 | 0.78 | ALDH1A1 (0.70) | KMT2AMEN1ALDH1A1POLBHDAC6 | |
| SCHEMBL1796314 | 0.78 | POLB (0.93) | KMT2AMEN1ALDH1A1POLBHDAC6 | |
| SCHEMBL8610620 | 0.77 | ALDH1A1 (0.64) | ALDH1A1POLBHDAC6HDAC8HDAC3 | |
| SCHEMBL14645424 | 0.76 | ALDH1A1 (0.68) | ALDH1A1POLBCA1CA2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0467621-B1 | N-phenyl-N'-alkylsulfonylureas, process for their preparation and antitumor compositions containing them | LILLY CO ELI (US) | 1994-06-15 | — | — | EP | claimed |
| EP-0467621-A1 | N-phenyl-N'-alkylsulfonylureas, process for their preparation and antitumor compositions containing them | ELI LILLY AND COMPANY (US) | 1992-01-22 | — | — | EP | claimed |