Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA2 | P47869 | 10/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 10/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 9/20 | 0.36 |
| ▸ | GABRP | O00591 | 4/20 | 0.36 |
| ▸ | GABRD | O14764 | 4/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 4/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.36 |
| ▸ | GABRA4 | P48169 | 4/20 | 0.36 |
| ▸ | GABRE | P78334 | 4/20 | 0.36 |
| ▸ | GABRA6 | Q16445 | 4/20 | 0.36 |
| ▸ | GABRG1 | Q8N1C3 | 4/20 | 0.36 |
| ▸ | GABRG3 | Q99928 | 4/20 | 0.36 |
| ▸ | GABRQ | Q9UN88 | 4/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | JUN | P05412 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9723059 | 0.93 | NPSR1 (0.31) | GABRA2GABRB2NPSR1 | |
| SCHEMBL9340434 | 0.92 | GABRA2 (0.35) | GABRA2GABRB2GABRB3GABRPGABRD | |
| SCHEMBL9593760 | 0.91 | GABRA2 (0.36) | GABRA2GABRB2GABRB3GABRPGABRD | |
| SCHEMBL9723106 | 0.90 | GABRA2 (0.40) | GABRA2GABRB2GABRB3GABRPGABRD | |
| SCHEMBL9581512 | 0.89 | SORT1 (0.38) | GABRA2GABRB2GABRB3GABRPGABRD | |
| SCHEMBL9723081 | 0.89 | NPSR1 (0.35) | GABRA2GABRB2GABRB3GABRPGABRD | |
| SCHEMBL9582023 | 0.88 | GABRA2 (0.36) | GABRA2GABRB2GABRB3GABRPGABRD | |
| SCHEMBL9592805 | 0.88 | GABRA2 (0.33) | GABRA2GABRB2GABRB3GABRPGABRD | |
| SCHEMBL9341537 | 0.87 | TDP1 (0.44) | — | |
| SCHEMBL9581520 | 0.84 | GABRA2 (0.33) | GABRA2GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0338686-B1 | Pyrimidinone derivatives | ZENECA LTD (GB) | 1994-06-22 | — | — | EP | disclosed |
| US-5149810-A | Chemical intermediates for insecticides | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-09-22 | — | — | US | disclosed |
| US-5077297-A | Insecticides | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-12-31 | — | — | US | disclosed |
| EP-0338686-A2 | Pyrimidinone derivatives | ZENECA LIMITED (GB) | 1989-10-25 | — | — | EP | disclosed |