Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9339176 | 0.93 | KMT2A (0.54) | KMT2ASMN1; SMN2ALDH1A1MEN1PKM | |
| SCHEMBL9339183 | 0.88 | KMT2A (0.55) | KMT2ASMN1; SMN2ALDH1A1MEN1HTR1A | |
| SCHEMBL9339728 | 0.83 | TSHR (0.51) | KMT2ASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL9339746 | 0.82 | SMN1; SMN2 (0.53) | KMT2ASMN1; SMN2ALDH1A1MEN1HTR1A | |
| SCHEMBL9339105 | 0.81 | KMT2A (0.58) | KMT2ASMN1; SMN2MEN1HTR1AHTR2A | |
| SCHEMBL9341043 | 0.79 | KMT2A (0.54) | KMT2ASMN1; SMN2MEN1HTR2A | |
| SCHEMBL9339739 | 0.78 | EPHX2 (0.54) | KMT2ASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL9343014 | 0.76 | KMT2A (0.51) | KMT2AMEN1HTR1A | |
| SCHEMBL9339094 | 0.75 | ALDH1A1 (0.52) | KMT2ASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL9343034 | 0.75 | MEN1 (0.52) | KMT2ASMN1; SMN2ALDH1A1MEN1DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5360808-A | Cardiovascular disorders, antispasmodic agents, hypotensive disorders, brains, anticonvulsants and antiepileptics | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-11-01 | — | — | US | disclosed |
| EP-0556738-A1 | Pyridinylcarbonylaminoalkyl-dihydro-oxo-pyridines, their production and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-08-25 | — | — | EP | disclosed |