Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | HTR4 | Q13639 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.49 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.49 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.49 |
| ▸ | HTR1D | P28221 | 1/20 | 0.49 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
| ▸ | HTR3A | P46098 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9344902 | 0.87 | MEN1 (0.53) | HTR4CHRM4CHRM5ADRA2CCHRM3 | |
| SCHEMBL7260342 | 0.84 | HTR4 (0.64) | ALOX15SMN1; SMN2HTR4HTT | |
| SCHEMBL13036127 | 0.80 | HTR4 (0.80) | HTR4 | |
| Hydrochloric Acid SCHEMBL9340409 | 0.78 | HTR3A (0.47) | HTR4CHRM4CHRM5ADRA2CCHRM3 | |
| SCHEMBL7400348 | 0.77 | HTR4 (0.45) | HTR4CHRM4CHRM5ADRA2CCHRM3 | |
| Hydrochloric Acid SCHEMBL9540261 | 0.77 | HTR3A (0.49) | HTR4CHRM4CHRM5ADRA2CCHRM3 | |
| SCHEMBL9341292 | 0.76 | KDM4E (0.49) | HTT | |
| SCHEMBL9341467 | 0.75 | HTR4 (0.71) | ALOX15HTR4 | |
| SCHEMBL9345077 | 0.75 | KDM4E (0.46) | HTR4HTT | |
| SCHEMBL7300823 | 0.74 | CYP2C9 (0.74) | ALOX15HTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0600955-A1 | 5-HT4 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-06-15 | — | — | EP | disclosed |
| WO-1993003725-A1 | 5-HT4 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1993-03-04 | — | — | WO | disclosed |