SCHEMBL9340930

SCHEMBL9340930

C[C@H]1CC[C@H](c2ccc(OC(F)(F)C(F)F)cc2)CC1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR2 Q92731 1/20 0.47
EPHX2 P34913 2/20 0.38
TRPV1 Q8NER1 3/20 0.37
HCRTR1 O43613 1/20 0.35
HCRTR2 O43614 1/20 0.35
CACNA1G O43497 1/20 0.35
CACNA1H O95180 1/20 0.35
CACNA1I Q9P0X4 1/20 0.35
HRH3 Q9Y5N1 2/20 0.35
L3MBTL1 Q9Y468 1/20 0.34
ALDH1A1 P00352 2/20 0.33
HTR2C P28335 2/20 0.33
TSHR P16473 1/20 0.33
HSD17B10 Q99714 1/20 0.33
MMP13 P45452 1/20 0.33
MMP14 P50281 1/20 0.33
KCNH2 Q12809 1/20 0.33
KDM1A O60341 1/20 0.33
RCOR1 Q9UKL0 1/20 0.33
SLC6A2 P23975 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9340934 1.00 ESR2 (0.47) ESR2EPHX2TRPV1HCRTR1HCRTR2
SCHEMBL7913725 0.89 ALDH1A1 (0.47) ESR2EPHX2CACNA1GCACNA1HCACNA1I
SCHEMBL7914005 0.86 ALDH1A1 (0.43) ESR2EPHX2CACNA1GCACNA1HCACNA1I
SCHEMBL7911165 0.86 ALDH1A1 (0.43) ESR2EPHX2CACNA1GCACNA1HCACNA1I
SCHEMBL14229002 0.85 ESR2 (0.52) ESR2EPHX2TRPV1HRH3L3MBTL1
SCHEMBL6452730 0.82 HRH3 (0.34) ESR2EPHX2TRPV1HCRTR1HCRTR2
SCHEMBL6452735 0.82 HRH3 (0.34) ESR2EPHX2TRPV1HCRTR1HCRTR2
SCHEMBL7917608 0.82 ALDH1A1 (0.41) ESR2EPHX2CACNA1GCACNA1HCACNA1I
SCHEMBL9340493 0.82 CYP2C9 (0.49) ESR2TRPV1HCRTR1HCRTR2CACNA1G
SCHEMBL9340496 0.82 CYP2C9 (0.49) ESR2TRPV1HCRTR1HCRTR2CACNA1G

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5348677-A Electro-optical liquid crystal display element MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1994-09-20 US disclosed
US-5196140-A ELECTRO-OPTICAL LIQUID CRYSTAL DISPLAY ELEMENT MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1993-03-23 US disclosed