Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 2/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29140939 | 0.83 | HDAC1 (0.64) | MTORHDAC1HDAC6NPC1RAB9A | |
| SCHEMBL7613993 | 0.81 | MTOR (0.53) | MTORHDAC1HDAC6NPC1RAB9A | |
| SCHEMBL9337338 | 0.81 | MEN1 (0.62) | MTORNPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL3483320 | 0.81 | HDAC1 (0.59) | MTORHDAC1HDAC6NPC1RAB9A | |
| SCHEMBL9340742 | 0.78 | MEN1 (0.54) | MTORHDAC1HDAC6NPC1RAB9A | |
| SCHEMBL9340888 | 0.77 | MTOR (0.56) | MTORNPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL7614921 | 0.75 | LMNA (0.56) | MTORHDAC1HDAC6NPC1RAB9A | |
| SCHEMBL9337294 | 0.75 | HDAC6 (0.52) | HDAC1HDAC6KMT2AMEN1NPSR1 | |
| SCHEMBL9337457 | 0.74 | MTOR (0.56) | MTORNPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL9339206 | 0.74 | ICMT (0.57) | HDAC1HDAC6KMT2AMEN1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5332750-A | Treatment of hypertension, aldosteronism, cardiac insufficienc y | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1994-07-26 | — | — | US | disclosed |
| EP-0530702-A1 | 1,2-dihydro-2-oxopyridines as angiotensin II antagonists | MERCK PATENT GmbH (DE) | 1993-03-10 | — | — | EP | disclosed |