Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 12/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 5/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | APAF1 | O14727 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | TYMP | P19971 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9337584 | 0.85 | MAPT (0.37) | KDM4EALDH1A1HPGDSMN1; SMN2HSD17B10 | |
| SCHEMBL9340882 | 0.82 | GPR84 (0.39) | KDM4EALDH1A1HPGDSMN1; SMN2TSHR | |
| SCHEMBL9341346 | 0.80 | ALDH1A1 (0.41) | KDM4EALDH1A1HPGDSMN1; SMN2TSHR | |
| SCHEMBL9337173 | 0.79 | MAPT (0.36) | KDM4EALDH1A1HPGDSMN1; SMN2HSD17B10 | |
| SCHEMBL9230501 | 0.78 | KDM4E (0.41) | KDM4EALDH1A1HPGDSMN1; SMN2TSHR | |
| SCHEMBL9341177 | 0.77 | MAPT (0.35) | KDM4EALDH1A1HPGDSMN1; SMN2HSD17B10 | |
| SCHEMBL9337293 | 0.76 | GPR84 (0.44) | KDM4EALDH1A1HPGDTSHRHSD17B10 | |
| SCHEMBL9339168 | 0.75 | MAPT (0.37) | KDM4EALDH1A1HPGDTSHRHSD17B10 | |
| SCHEMBL9337400 | 0.73 | KDM4E (0.38) | KDM4EALDH1A1HPGDSMN1; SMN2TSHR | |
| SCHEMBL9337476 | 0.73 | MAPT (0.38) | KDM4EALDH1A1HPGDSMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5332750-A | Treatment of hypertension, aldosteronism, cardiac insufficienc y | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1994-07-26 | — | — | US | disclosed |
| EP-0530702-A1 | 1,2-dihydro-2-oxopyridines as angiotensin II antagonists | MERCK PATENT GmbH (DE) | 1993-03-10 | — | — | EP | disclosed |