SCHEMBL934101

SCHEMBL934101

COc1cc(Br)cc(F)c1N

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.48
NPSR1 Q6W5P4 2/20 0.48
POLB P06746 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
APP P05067 3/20 0.39
ERN1 O75460 1/20 0.38
ALOX15 P16050 1/20 0.38
ALOX12 P18054 1/20 0.38
NQO2 P16083 2/20 0.36
EP300 Q09472 1/20 0.35
HTR2A P28223 1/20 0.35
HTR2C P28335 1/20 0.35
TAAR1 Q96RJ0 1/20 0.35
ALDH1A1 P00352 2/20 0.34
GAA P10253 1/20 0.34
PRNP P04156 1/20 0.33
RXFP1 Q9HBX9 1/20 0.33
CA1 P00915 1/20 0.33
CA2 P00918 1/20 0.33
CA9 Q16790 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bromide SCHEMBL15880338 0.98 MAPT (0.47) MAPTNPSR1POLBL3MBTL1APP
SCHEMBL30693943 0.86 MAPT (0.36) MAPTNPSR1POLBL3MBTL1CA1
SCHEMBL1000103 0.84 MAPT (0.58) MAPTNPSR1POLBL3MBTL1APP
SCHEMBL22053026 0.79 HSD17B10 (0.39) MAPTPOLBL3MBTL1ALDH1A1GAA
SCHEMBL935630 0.78 TUBB1 (0.40) MAPTNPSR1POLBL3MBTL1APP
SCHEMBL29448365 0.78 TUBB1 (0.40) MAPTNPSR1POLBL3MBTL1APP
SCHEMBL2498762 0.78 MAPT (0.52) MAPTNPSR1POLBL3MBTL1APP
SCHEMBL31261040 0.78 MAPT (0.42) MAPTNPSR1POLBL3MBTL1EP300
SCHEMBL31211203 0.78 MAPT (0.57) MAPTNPSR1POLBL3MBTL1APP
SCHEMBL13186794 0.78 MAPT (0.42) MAPTNPSR1POLBL3MBTL1EP300

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260098032-A1 METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION PMV PHARMACEUTICALS INC (US) 2026-04-09 US disclosed
EP-4644387-A2 METHODS AND COMPOUNDS FOR RESTORING MUTANT P53 FUNCTION PMV Pharmaceuticals, Inc. (US) 2025-11-05 EP disclosed
US-12428406-B2 Methods and compounds for restoring mutant p53 function PMV PHARMACEUTICALS, INC. (US) 2025-09-30 US disclosed
US-20250154169-A1 COMPOUNDS AND METHODS FOR MODULATING SPLICING REMIX THERAPEUTICS INC. 2025-05-15 US disclosed
CN-119912402-A FTO inhibitor and preparation method and application thereof 中国科学院上海药物研究所 2025-05-02 CN disclosed
US-20250042917-A1 THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF GENENTECH, INC. (US) 2025-02-06 US disclosed
US-20240400591-A1 COMPOUNDS TARGETING MUTANT OF P53 JACOBIO PHARMACEUTICALS CO., LTD. (CN) 2024-12-05 US disclosed
US-12139496-B2 Therapeutic compounds and methods of use thereof GENENTECH, INC. (US) 2024-11-12 US disclosed
EP-4395892-A1 COMPOUNDS AND METHODS FOR MODULATING SPLICING Remix Therapeutics Inc. (US) 2024-07-10 EP disclosed
CN-118302426-A Compounds and methods for modulating splicing 雷密克斯医疗公司 2024-07-05 CN disclosed
CN-111936494-A Substituted hydro-pyrido-azines as sodium channel inhibitors 豪夫迈·罗氏有限公司 2020-11-13 CN disclosed
WO-2019191702-A1 SUBSTITUTED HYDRO-PYRIDO-AZINES AS SODIUM CHANNEL INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2019-10-03 WO disclosed
US-20190300544-A1 THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF GENENTECH, INC. (US) 2019-10-03 US disclosed
CN-105658642-A Fibroblast growth factor receptor inhibitors 蓝图药品公司 2016-06-08 CN disclosed
CN-104540809-A Inhibitors of fibroblast growth factor receptors BLUEPRINT MEDICINES 2015-04-22 CN disclosed
CN-102245609-A Imidazopyridazinecarbonitriles useful as kinase inhibitors BRISTOL MYERS SQUIBB CO 2011-11-16 CN disclosed
CN-102123991-A 2-arylaminoquinazolines for the treatment of proliferative diseases NOVARTIS AG 2011-07-13 CN disclosed
WO-2011007091-A1 DERIVATIVES OF 5,6-BISARYL-2-PYRIDINE-CARBOXAMIDE, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF AS UROTENSIN-II RECEPTOR ANTAGONISTS SANOFI-AVENTIS (FR) 2011-01-20 WO disclosed
CN-101652352-A Quinazolines for PDK1 inhibition NOVARTIS VACCINES & DIAGNOSTIC 2010-02-17 CN disclosed
CN-101454294-A Quinazolines for pdk1 inhibition NOVARTIS AG (CH) 2009-06-10 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250042917-A1 THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF REN, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, C3AR1 MAPT 2968/4885NPSR1 104/4885POLB 4010/4885
US-20190300544-A1 THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF REN, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, C3AR1 MAPT 2968/4885NPSR1 104/4885POLB 4010/4885
US-12428406-B2 Methods and compounds for restoring mutant p53 function TP53, TP53BP1, KRAS MAPT 4269/4885NPSR1 4702/4885POLB 70/4885
US-20240400591-A1 COMPOUNDS TARGETING MUTANT OF P53 TP53, TP53BP1, MDM2 MAPT 2352/4885NPSR1 4634/4885POLB 73/4885
US-20250154169-A1 COMPOUNDS AND METHODS FOR MODULATING SPLICING RBM17, SNRPA, SNRPA1 MAPT 3414/4885NPSR1 2006/4885POLB 289/4885
US-20260098032-A1 METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION TP53, TP53BP1, MDM2 MAPT 2371/4885NPSR1 4616/4885POLB 283/4885
US-12139496-B2 Therapeutic compounds and methods of use thereof REN, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, C3AR1 MAPT 2968/4885NPSR1 104/4885POLB 4010/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.