SCHEMBL9344489

SCHEMBL9344489

Nc1ccc(C(=O)NCCNC(=O)c2ccc(N)cc2)cc1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.68
MAPT P10636 1/20 0.68
HIF1A Q16665 1/20 0.68
SLC22A6 Q4U2R8 1/20 0.68
SLC22A8 Q8TCC7 1/20 0.68
HDAC3 O15379 2/20 0.67
HDAC4 P56524 2/20 0.67
HDAC1 Q13547 2/20 0.67
HDAC7 Q8WUI4 2/20 0.67
HDAC2 Q92769 2/20 0.67
HDAC10 Q969S8 2/20 0.67
HDAC11 Q96DB2 2/20 0.67
HDAC8 Q9BY41 2/20 0.67
HDAC6 Q9UBN7 2/20 0.67
HDAC9 Q9UKV0 2/20 0.67
HDAC5 Q9UQL6 2/20 0.67
LMNA P02545 4/20 0.66
TSHR P16473 2/20 0.66
ALDH1A1 P00352 2/20 0.66
MAPK1 P28482 2/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1509407 0.94 KDM4E (0.61) KDM4EMAPTHIF1ASLC22A6SLC22A8
SCHEMBL1509365 0.94 KDM4E (0.61) KDM4EMAPTHIF1ASLC22A6SLC22A8
SCHEMBL24003402 0.92 HDAC3 (0.59) KDM4EMAPTHIF1ASLC22A6SLC22A8
SCHEMBL3127125 0.92 KDM4E (0.65) KDM4EMAPTHIF1ASLC22A6SLC22A8
SCHEMBL11230329 0.91 KDM4E (0.63) KDM4EMAPTHIF1ASLC22A6SLC22A8
SCHEMBL12515200 0.91 KDM4E (0.63) KDM4EMAPTHIF1ASLC22A6SLC22A8
SCHEMBL23222134 0.90 LMNA (0.61) KDM4EMAPTHIF1ASLC22A6SLC22A8
SCHEMBL853629 0.90 KDM4E (0.61) KDM4EMAPTHIF1ASLC22A6SLC22A8
SCHEMBL9419699 0.90 MAPK1 (0.65) KDM4EMAPTHIF1ASLC22A6SLC22A8
SCHEMBL11619588 0.90 TSHR (0.70) KDM4EMAPTHIF1ASLC22A6SLC22A8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4072664-A TEREPHTHALIC ACID, P-PHENYLENEDIAMINE; FILAMENTS TOYOBO CO., LTD. (JA) 1978-02-07 US claimed
EP-0391646-B1 A process for the preparation of a poly(paraphenylene terephthalamide) fibrous gel composition and a process to produce poly (Paraphenylene terephthalamide) paper from the composition DU PONT (US) 1994-06-15 EP disclosed
US-5021123-A Process for producing paper from a poly(paraphenylene terephthalamide) fibrous gel E. I. DU PONT DE NEMOURS AND COMPANY (US) 1991-06-04 US disclosed
EP-0391646-A1 A process for the preparation of a poly(paraphenylene terephthalamide) fibrous gel composition and a process to produce poly (Paraphenylene terephthalamide) paper from the composition E.I. DU PONT DE NEMOURS AND COMPANY (US) 1990-10-10 EP disclosed
US-4959453-A Process for the preparation of a poly(paraphenylene terephthalamide)fibrous gel composition and a process to produce poly(paraphenylene terephthalamide) paper from the composition E. I. DU PONT DE NEMOURS AND COMPANY (US) 1990-09-25 US disclosed
US-4732975-A ORGANIC PIGMENTS HOECHST AKTIENGESELLSCHAFT (DE) 1988-03-22 US disclosed
US-4591635-A DYES FOR LEATHER OR PAPER SANDOZ LTD. (CH) 1986-05-27 US disclosed
EP-0055380-B1 DISAZO COMPOUNDS, METHODS FOR THEIR PREPARATION AND THEIR USE HOECHST AKTIENGESELLSCHAFT (DE) 1984-06-27 EP disclosed
US-4072664-A TEREPHTHALIC ACID, P-PHENYLENEDIAMINE; FILAMENTS TOYOBO CO., LTD. (JA) 1978-02-07 US disclosed
US-4072664-A TEREPHTHALIC ACID, P-PHENYLENEDIAMINE; FILAMENTS TOYOBO CO., LTD. (JA) 1978-02-07 US disclosed
US-4072664-A TEREPHTHALIC ACID, P-PHENYLENEDIAMINE; FILAMENTS TOYOBO CO., LTD. (JA) 1978-02-07 US disclosed