Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | ELANE | P08246 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.38 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.37 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.37 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8487905 | 1.00 | KMT2A (0.43) | KMT2AALDH1A1ELANEL3MBTL1MEN1 | |
| SCHEMBL9407814 | 1.00 | KMT2A (0.43) | KMT2AALDH1A1ELANEL3MBTL1MEN1 | |
| SCHEMBL13531037 | 0.87 | ELANE (0.37) | KMT2AALDH1A1ELANEL3MBTL1MEN1 | |
| SCHEMBL14199219 | 0.81 | KMT2A (0.46) | KMT2AALDH1A1ELANEL3MBTL1MEN1 | |
| SCHEMBL9924408 | 0.81 | KMT2A (0.46) | KMT2AALDH1A1ELANEL3MBTL1MEN1 | |
| SCHEMBL13845044 | 0.78 | KMT2A (0.40) | KMT2AALDH1A1ELANEL3MBTL1MEN1 | |
| SCHEMBL14574449 | 0.78 | KMT2A (0.40) | KMT2AALDH1A1ELANEL3MBTL1MEN1 | |
| SCHEMBL5963538 | 0.77 | ELANE (0.51) | KMT2AALDH1A1ELANEMEN1POLB | |
| SCHEMBL5963957 | 0.77 | RIPK1 (0.49) | KMT2AELANEMEN1RIPK1HPGD | |
| SCHEMBL5963531 | 0.77 | ELANE (0.44) | KMT2AELANEMEN1POLBRIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7358378-B2 | Processes for the preparation of paclitaxel | FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2008-04-15 | — | — | US | disclosed |
| US-5300638-A | Reacting imine derivative of threonine with an acetyl halide in the presence of a base; preferential | BRISTOL-MYERS SQUIBB COMPANY (US) | 1994-04-05 | — | — | US | disclosed |
| EP-0582469-A2 | Process for preparing taxol-type compound from beta-lactam precursors | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1994-02-09 | — | — | EP | disclosed |
| CN-1069028-A | The asymmetric synthesis of taxol side chain | BRISTOL MYERS SQUIBB CO (US) | 1993-02-17 | — | — | CN | disclosed |
| EP-0525589-A1 | Asymmetric synthesis of taxol side chain | Bristol-Myers Squibb Company (US) | 1993-02-03 | — | — | EP | disclosed |