Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.30 |
| ▸ | LMNA | P02545 | 2/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11838997 | 0.75 | ALDH1A1 (0.37) | ALDH1A1KDM4EGAATSHREPHX2 | |
| SCHEMBL28310143 | 0.74 | LMNA (0.35) | ALDH1A1LMNA | |
| SCHEMBL544750 | 0.74 | LMNA (0.35) | ALDH1A1LMNA | |
| SCHEMBL8594226 | 0.74 | ALDH1A1 (0.39) | ALDH1A1KDM4EGAATSHRL3MBTL1 | |
| Hydrochloric Acid SCHEMBL11838991 | 0.73 | ALDH1A1 (0.36) | ALDH1A1KDM4EGAATSHREPHX2 | |
| SCHEMBL13502946 | 0.73 | ALDH1A1 (0.40) | ALDH1A1TSHREPHX2L3MBTL1LMNA | |
| SCHEMBL261295 | 0.72 | — | — | |
| SCHEMBL22558253 | 0.72 | ALDH1A1 (0.39) | ALDH1A1KDM4EGAATSHREPHX2 | |
| SCHEMBL11128264 | 0.72 | — | — | |
| SCHEMBL2945712 | 0.71 | ALDH1A1 (0.35) | ALDH1A1KDM4EGAATSHREPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0359464-B1 | Heat resistant polyvinyl chloride copolymer and preparation process of the copolymer | MITSUI TOATSU CHEMICALS (JP) | 1994-07-20 | — | — | EP | disclosed |
| US-5166271-A | N-substituted maleimide with vinyl chloride graft polymerized | MITSUI TOATSU CHEMICALS, INC. (JP) | 1992-11-24 | — | — | US | disclosed |
| EP-0359464-A2 | Heat resistant polyvinyl chloride copolymer and preparation process of the copolymer | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1990-03-21 | — | — | EP | disclosed |