Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.80 |
| ▸ | GAA | P10253 | 1/20 | 0.80 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.80 |
| ▸ | KCNH3 | Q9ULD8 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | GPR68 | Q15743 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | RAD52 | P43351 | 1/20 | 0.51 |
| ▸ | ESR1 | P03372 | 1/20 | 0.51 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | APP | P05067 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10055028 | 0.90 | LMNA (0.65) | LMNAGAAL3MBTL1KCNH3SMN1; SMN2 | |
| SCHEMBL3298289 | 0.83 | KCNH3 (0.73) | LMNAGAAL3MBTL1KCNH3RAD52 | |
| SCHEMBL13879773 | 0.82 | LMNA (0.57) | LMNAGAAL3MBTL1KCNH3SMN1; SMN2 | |
| SCHEMBL9484727 | 0.82 | LMNA (0.61) | LMNAGAAL3MBTL1KCNH3SMN1; SMN2 | |
| SCHEMBL2805145 | 0.76 | KCNH3 (0.55) | LMNAGAAL3MBTL1KCNH3RAD52 | |
| SCHEMBL2591004 | 0.76 | RAD52 (0.68) | LMNAGAAL3MBTL1RAD52MAPT | |
| SCHEMBL15809873 | 0.74 | LMNA (0.53) | LMNAGAAL3MBTL1KCNH3SMN1; SMN2 | |
| SCHEMBL2590399 | 0.74 | RAD52 (0.70) | LMNARAD52MAPTAPP | |
| SCHEMBL3301514 | 0.73 | NPSR1 (0.74) | GAAKCNH3SMN1; SMN2GPR68RAD52 | |
| SCHEMBL14869398 | 0.73 | BCHE (0.65) | LMNAGAAL3MBTL1KCNH3RAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0378089-B1 | Method for the preparation of 2-amino-4-fluoropyrimidine derivatives | BASF AG (DE) | 1994-06-29 | — | — | EP | disclosed |
| US-5011927-A | Preparation of 2-amino-4-fluoropyrimidine derivatives | BASF AKTIENGESELLSCHAFT (DE) | 1991-04-30 | — | — | US | disclosed |
| EP-0378089-A1 | Method for the preparation of 2-amino-4-fluoropyrimidine derivatives | BASF Aktiengesellschaft (DE) | 1990-07-18 | — | — | EP | disclosed |