SCHEMBL9345488

SCHEMBL9345488

Clc1cc(C(Cl)Cl)nc(Cl)n1

nearest known ligand 0.33

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.33
ALOX15 P16050 1/20 0.33
TSHR P16473 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1706547 0.78 NOS3 (0.39) ALDH1A1ALOX15TSHR
SCHEMBL19024340 0.78 ADORA2A (0.37) ALDH1A1ALOX15TSHR
SCHEMBL11333973 0.75 TSHR (0.33) TSHR
SCHEMBL28418528 0.75 ESR1 (0.34)
Ammonia Solution, Strong SCHEMBL27915759 0.74 ALDH1A1 (0.50) ALDH1A1ALOX15TSHR
SCHEMBL218052 0.74
SCHEMBL25487217 0.70
Methyl Alcohol SCHEMBL29141832 0.67 ALDH1A1 (0.41) ALDH1A1ALOX15TSHR
Formaldehyde SCHEMBL27883709 0.67 ALDH1A1 (0.41) ALDH1A1ALOX15TSHR
SCHEMBL3605813 0.66 MEN1 (0.35)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0458109-B1 Side chain chlorination of alkylated pyridine or pyrimidine derivatives BAYER AG (DE) 1994-07-13 EP disclosed
US-5198549-A SIDE-CHAIN CHLORINATION OF ALKYLATED NITROGEN HETEROAROMATICS BAYER AKTIENGESELLSCHAFT (DE) 1993-03-30 US disclosed
EP-0458109-A1 Side chain chlorination of alkylated pyridine or pyrimidine derivatives BAYER AG (DE) 1991-11-27 EP disclosed
EP-0065479-A2 Reactive dyestuffs, process for their preparation and their use in dyeing and printing materials containing hydroxyl groups or nitrogen BAYER AG (DE) 1982-11-24 EP disclosed