Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 9/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.50 |
| ▸ | NPC1 | O15118 | 8/20 | 0.50 |
| ▸ | STAT3 | P40763 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | CASP3 | P42574 | 2/20 | 0.49 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.49 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.48 |
| ▸ | RELA | Q04206 | 4/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9449567 | 1.00 | RAB9A (0.52) | RAB9AMAPTL3MBTL1SMN1; SMN2NPC1 | |
| SCHEMBL9346712 | 1.00 | RAB9A (0.52) | RAB9AMAPTL3MBTL1SMN1; SMN2NPC1 | |
| SCHEMBL9343407 | 1.00 | RAB9A (0.52) | RAB9AMAPTL3MBTL1SMN1; SMN2NPC1 | |
| SCHEMBL9341801 | 1.00 | RAB9A (0.52) | RAB9AMAPTL3MBTL1SMN1; SMN2NPC1 | |
| SCHEMBL10337555 | 1.00 | RAB9A (0.52) | RAB9AMAPTL3MBTL1SMN1; SMN2NPC1 | |
| SCHEMBL10337414 | 1.00 | RAB9A (0.52) | RAB9AMAPTL3MBTL1SMN1; SMN2NPC1 | |
| SCHEMBL9343400 | 1.00 | RAB9A (0.52) | RAB9AMAPTL3MBTL1SMN1; SMN2NPC1 | |
| SCHEMBL27262428 | 0.91 | CASP3 (0.54) | RAB9AMAPTL3MBTL1SMN1; SMN2NPC1 | |
| SCHEMBL27262488 | 0.91 | CASP3 (0.54) | RAB9AMAPTL3MBTL1SMN1; SMN2NPC1 | |
| SCHEMBL27262965 | 0.91 | CASP3 (0.54) | RAB9AMAPTL3MBTL1SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0373191-B1 | HETEROCYCLIC 1,2-DIFLUOROBENZENE DERIVATIVES | MERCK PATENT GMBH (DE) | 1994-07-13 | — | — | EP | disclosed |
| US-5209866-A | HETEROCYCLIC 1,2-DIFLUOROBENZENE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1993-05-11 | — | — | US | disclosed |
| US-5198149-A | 2,3-Difluoro-p-Phenylene Group | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1993-03-30 | — | — | US | disclosed |
| EP-0332006-B1 | SMECTIC LIQUID-CRYSTAL COMPOSITION | MERCK PATENT GmbH (DE) | 1993-01-13 | — | — | EP | disclosed |
| EP-0362317-A1 | SMECTIC LIQUID CRYSTAL MEDIUM | MERCK PATENT GmbH (DE) | 1990-04-11 | — | — | EP | disclosed |
| WO-1989008690-A1 | SMECTIC LIQUID CRYSTAL MEDIUM | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1989-09-21 | — | — | WO | disclosed |
| EP-0332024-A1 | Heterocyclic derivatives of 1,2-difluorobenzene | MERCK PATENT GmbH (DE) | 1989-09-13 | — | — | EP | disclosed |
| EP-0332006-A1 | Smectic liquid-crystal composition | MERCK PATENT GmbH (DE) | 1989-09-13 | — | — | EP | disclosed |