Cidofovir Anhydrous

Cidofovir Anhydrous

SCHEMBL934593

Nc1ccn(C[C@@H](CO)OCP(=O)(O)O)c(=O)n1.O=P(O)(O)O.O=P(O)(O)O

nearest known ligand 0.98

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

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

The experimentally established mechanism targets of Cidofovir Anhydrous. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
FGFR1 known ✓ P11362 4/20 0.98
SLC22A6 Q4U2R8 1/20 0.95
TYMP P19971 3/20 0.49
HPRT1 P00492 7/20 0.44
CYP3A4 P08684 1/20 0.34
NT5E P21589 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Cidofovir Anhydrous SCHEMBL2468382 1.00 FGFR1 (0.98) FGFR1SLC22A6TYMPHPRT1CYP3A4
Cidofovir Anhydrous SCHEMBL27629017 1.00 FGFR1 (0.98) FGFR1SLC22A6TYMPHPRT1CYP3A4
Cidofovir Anhydrous SCHEMBL1389452 0.99 FGFR1 (1.00) FGFR1SLC22A6TYMPHPRT1CYP3A4
Cidofovir Anhydrous SCHEMBL3948 0.99 FGFR1 (1.00) FGFR1SLC22A6TYMPHPRT1CYP3A4
Cidofovir Anhydrous SCHEMBL14682730 0.99 FGFR1 (1.00) FGFR1SLC22A6TYMPHPRT1CYP3A4
Cidofovir Anhydrous SCHEMBL151807 0.99 FGFR1 (1.00) FGFR1SLC22A6TYMPHPRT1CYP3A4
Cidofovir Anhydrous SCHEMBL2946566 0.98 SLC22A6 (1.00) FGFR1SLC22A6TYMPHPRT1CYP3A4
Cidofovir Anhydrous SCHEMBL2946561 0.98 SLC22A6 (1.00) FGFR1SLC22A6TYMPHPRT1CYP3A4
Cidofovir Anhydrous SCHEMBL20770422 0.98 FGFR1 (0.98) FGFR1SLC22A6TYMPHPRT1CYP3A4
Cidofovir Anhydrous SCHEMBL12988503 0.98 SLC22A6 (1.00) FGFR1SLC22A6TYMPHPRT1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12485131-B2 Formulations of brincidofovir EMERGENT BIODEFENSE OPERATIONS LANSING LLC (US) 2025-12-02 US disclosed
EP-3474822-B1 FORMULATIONS OF BRINCIDOFOVIR EMERGENT BIODEFENSE OPERATIONS LANSING LLC (US) 2025-07-09 EP disclosed
CN-119139329-A Preparation of brinzdofovir 应急生物防御行动兰辛有限责任公司 2024-12-17 CN disclosed
CN-118416082-A Preparation of brinzdofovir 应急生物防御行动兰辛有限责任公司 2024-08-02 CN disclosed
CN-117795096-A Methods, compositions and kits for preparing sequencing libraries 吉复生物科技有限公司 2024-03-29 CN disclosed
CN-117624239-A Cytidine derivatives and process for preparing same 中国人民解放军军事科学院军事医学研究院 2024-03-01 CN disclosed
EP-4295853-A2 FORMULATIONS OF BRINCIDOFOVIR Emergent BioDefense Operations Lansing LLC (US) 2023-12-27 EP disclosed
US-20230210873-A1 FORMULATIONS OF BRINCIDOFOVIR WELLS FARGO BANK, NATIONAL ASSOCIATION 2023-07-06 US disclosed
US-20230172961-A1 THERAPEUTICS FOR COVID-19 THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2023-06-08 US disclosed
CN-114569547-A Preparation of brinciclovir 奇默里克斯公司 2022-06-03 CN disclosed
EP-2371369-A1 EGFR inhibitor and antiviral agent for simultaneous, separate or sequential use in the treatment and/or prevention and/or palliation of cancer Institut Gustave Roussy (IGR) (FR) 2011-10-05 EP disclosed
US-8017135-B1 Lipid-drug conjugates for local therapy of eye diseases THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2011-09-13 US disclosed
WO-2011053812-A1 METHODS OF TREATING VIRAL ASSOCIATED DISEASES CHIMERIX, INC. (US) 2011-05-05 WO disclosed
WO-2011003194-A1 ONCOLYTIC VIRUSES AND METHODS FOR TREATING NEOPLASTIC DISORDERS THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) 2011-01-13 WO disclosed
US-20100137341-A1 DNA POLYMERASE INHIBITORS COMPOSITION AND METHODS THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA 2010-06-03 US disclosed
EP-2155209-A1 DNA POLYMERASE INHIBITORS COMPOSITION AND METHODS The Trustees of the University of Pennsylvania (US) 2010-02-24 EP disclosed
US-20090192077-A1 North-2'deoxy -methanocarbathymidines as antiviral agents for treatment of kaposi's sarcoma-associated herpes virus HEALTH AND HUMAN SERVICES, THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF 2009-07-30 US disclosed
US-20090181931-A1 ANTIVIRAL ACTIVITY OF CIDOFOVIR AGAINST ONCOLYTIC VIRUSES ONCOLYS BIOPHARMA, INC. (JP) 2009-07-16 US disclosed
WO-2008134033-A1 DNA POLYMERASE INHIBITORS COMPOSITION AND METHODS THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2008-11-06 WO disclosed
WO-2006113204-A2 THYMIDINE DERIVATIVES FOR TREATMEMT OF KAPOSI'S SARCOMA THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2006-10-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230210873-A1 FORMULATIONS OF BRINCIDOFOVIR SAMHD1, UGT2B7, HPRT1 FGFR1 1658/4885SLC22A6 523/4885TYMP 15/4885
US-20230172961-A1 THERAPEUTICS FOR COVID-19 ACE, ACE2, PNP FGFR1 4184/4885SLC22A6 3129/4885TYMP 29/4885
US-20090181931-A1 ANTIVIRAL ACTIVITY OF CIDOFOVIR AGAINST ONCOLYTIC VIRUSES TYMP, DCTD, SAMHD1 FGFR1 3451/4885SLC22A6 2800/4885TYMP 1/4885
US-12485131-B2 Formulations of brincidofovir SAMHD1, UGT2B7, HPRT1 FGFR1 1658/4885SLC22A6 523/4885TYMP 15/4885
US-20090192077-A1 North-2'deoxy -methanocarbathymidines as antiviral agents for treatment of kaposi's sarcoma-associated herpes virus SAMHD1, TK2, DCTD FGFR1 4700/4885SLC22A6 797/4885TYMP 10/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.