Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 5/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.41 |
| ▸ | PLA2G7 | Q13093 | 4/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.39 |
| ▸ | HRH2 | P25021 | 2/20 | 0.39 |
| ▸ | HRH1 | P35367 | 2/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9591416 | 1.00 | TRPV4 (0.43) | TRPV4GPR119PLA2G7KDM1ACYP11B1 | |
| SCHEMBL9591619 | 0.90 | TRPV4 (0.43) | TRPV4GPR119PLA2G7KDM1ACYP11B1 | |
| SCHEMBL9348998 | 0.90 | TRPV4 (0.43) | TRPV4GPR119PLA2G7KDM1ACYP11B1 | |
| SCHEMBL9592266 | 0.90 | TRPV4 (0.43) | TRPV4GPR119PLA2G7KDM1ACYP11B1 | |
| SCHEMBL9346410 | 0.90 | TRPV4 (0.43) | TRPV4GPR119PLA2G7KDM1ACYP11B1 | |
| SCHEMBL9590450 | 0.90 | TRPV4 (0.43) | TRPV4GPR119PLA2G7KDM1ACYP11B1 | |
| SCHEMBL9591627 | 0.90 | TRPV4 (0.43) | TRPV4GPR119PLA2G7KDM1ACYP11B1 | |
| SCHEMBL9185192 | 0.89 | TRPV4 (0.42) | TRPV4GPR119PLA2G7KDM1ACYP11B1 | |
| SCHEMBL9185198 | 0.89 | TRPV4 (0.42) | TRPV4GPR119PLA2G7KDM1ACYP11B1 | |
| SCHEMBL9346370 | 0.88 | TRPV4 (0.41) | TRPV4GPR119PLA2G7KDM1ACYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0344557-B1 | Liquid crystal components with a trimethylenoxy group | HOFFMANN LA ROCHE (CH) | 1994-08-10 | — | — | EP | disclosed |
| US-5238600-A | IBIMETHYLENOXY CONTAINING LIQUID CRYSTAL COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 1993-08-24 | — | — | US | disclosed |
| EP-0344557-A2 | Liquid crystal components with a trimethylenoxy group | F. HOFFMANN-LA ROCHE AG (CH) | 1989-12-06 | — | — | EP | disclosed |