Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 3/20 | 0.37 |
| ▸ | MAOB | P27338 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9344620 | 0.97 | CRBN (0.40) | CRBNHRH3NPC1MAOAMAOB | |
| SCHEMBL9348876 | 0.96 | LMNA (0.40) | CRBNHRH3NPC1MAOAMAOB | |
| SCHEMBL9346429 | 0.96 | LMNA (0.40) | CRBNHRH3NPC1MAOAMAOB | |
| SCHEMBL9346067 | 0.95 | LMNA (0.39) | CRBNNPC1MAOAMAOBLMNA | |
| SCHEMBL9344573 | 0.95 | LMNA (0.39) | CRBNNPC1MAOAMAOBLMNA | |
| SCHEMBL9345732 | 0.95 | LMNA (0.39) | CRBNNPC1MAOAMAOBLMNA | |
| SCHEMBL9345716 | 0.95 | LMNA (0.39) | CRBNNPC1MAOAMAOBLMNA | |
| SCHEMBL9589384 | 0.95 | CRBN (0.37) | CRBNHRH3NPC1MAOAMAOB | |
| SCHEMBL9349152 | 0.93 | LMNA (0.41) | CRBNHRH3NPC1MAOAMAOB | |
| SCHEMBL9349131 | 0.93 | LMNA (0.41) | CRBNHRH3NPC1MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0344557-B1 | Liquid crystal components with a trimethylenoxy group | HOFFMANN LA ROCHE (CH) | 1994-08-10 | — | — | EP | disclosed |
| US-5238600-A | IBIMETHYLENOXY CONTAINING LIQUID CRYSTAL COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 1993-08-24 | — | — | US | disclosed |
| EP-0344557-A2 | Liquid crystal components with a trimethylenoxy group | F. HOFFMANN-LA ROCHE AG (CH) | 1989-12-06 | — | — | EP | disclosed |