Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | MAT2A | P31153 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | LYN | P07948 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9346570 | 0.86 | HPGD (0.45) | KMT2AKDM4EHPGDALDH1A1CDK5 | |
| SCHEMBL9346657 | 0.82 | LMNA (0.45) | NPC1RAB9AATMKDM4EPKM | |
| SCHEMBL9347480 | 0.81 | KDM4E (0.42) | KDM4EPKMTDP1SMN1; SMN2TNKS2 | |
| SCHEMBL9346549 | 0.79 | BRD4 (0.40) | MEN1NPC1RAB9AKMT2AKDM4E | |
| SCHEMBL9347518 | 0.78 | KDM4E (0.39) | MEN1KMT2AKDM4EPKMTDP1 | |
| SCHEMBL9347456 | 0.75 | PLK4 (0.46) | KDM4ETDP1SMN1; SMN2CHEK1HPGD | |
| SCHEMBL9347463 | 0.74 | PDE3B (0.41) | KMT2AKDM4EHPGDMAPK1ALDH1A1 | |
| SCHEMBL9346572 | 0.74 | GAA (0.43) | KDM4EHPGD | |
| SCHEMBL3179823 | 0.74 | PDE3B (0.58) | KDM4ESMN1; SMN2MAT2ATP53HPGD | |
| SCHEMBL3177677 | 0.73 | NPC1 (0.51) | MEN1NPC1RAB9AKMT2AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5294620-A | Hypotensive agents or compounds for cardiovascular disorders | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-03-15 | — | — | US | disclosed |
| US-5217976-A | Hypotensive agents, congestive heart failure | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-06-08 | — | — | US | disclosed |