Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 3/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.36 |
| ▸ | PDE9A | O76083 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9663795 | 0.80 | MAPK1 (0.35) | MAPK1CYP2C19KMT2A | |
| SCHEMBL9346549 | 0.80 | BRD4 (0.40) | PDE3BPDE3AKDM4EHPGDGAA | |
| SCHEMBL9347456 | 0.76 | PLK4 (0.46) | PDE3BPDE3AMAPK1KDM4EHPGD | |
| SCHEMBL9346572 | 0.75 | GAA (0.43) | KDM4EHPGDLMNATSHRBLM | |
| SCHEMBL9347398 | 0.74 | MEN1 (0.48) | MAPK1KDM4EHPGDALDH1A1KMT2A | |
| SCHEMBL3179823 | 0.72 | PDE3B (0.58) | PDE3BPDE3AKDM4EHPGDLMNA | |
| SCHEMBL7283404 | 0.71 | ALDH1A1 (0.51) | KDM4EHPGDLMNAGAAALDH1A1 | |
| SCHEMBL9347480 | 0.71 | KDM4E (0.42) | KDM4ELMNAALDH1A1 | |
| SCHEMBL9346657 | 0.70 | LMNA (0.45) | MAPK1KDM4EHPGDLMNAGAA | |
| SCHEMBL9346570 | 0.69 | HPGD (0.45) | KDM5AKDM4EHPGDCYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5294620-A | Hypotensive agents or compounds for cardiovascular disorders | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-03-15 | — | — | US | disclosed |
| US-5217976-A | Hypotensive agents, congestive heart failure | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-06-08 | — | — | US | disclosed |