Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | EP300 | Q09472 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.39 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 2/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9348332 | 0.97 | MAPT (0.45) | MAPTHPGDKDM4ECYP1A2CYP3A4 | |
| SCHEMBL10377542 | 0.90 | MAPT (0.44) | MAPTHPGDKDM4ECYP1A2CYP3A4 | |
| SCHEMBL9352380 | 0.90 | ALDH1A1 (0.46) | MAPTHPGDKDM4ECYP1A2CYP3A4 | |
| SCHEMBL9348282 | 0.90 | FEN1 (0.50) | MAPTHPGDKDM4ECYP1A2CYP3A4 | |
| SCHEMBL9348283 | 0.89 | MAPT (0.46) | MAPTHPGDKDM4ECYP1A2CYP3A4 | |
| SCHEMBL9348372 | 0.89 | FEN1 (0.49) | MAPTHPGDKDM4ECYP1A2CYP3A4 | |
| SCHEMBL10379180 | 0.88 | KAT2B (0.42) | MAPTKDM4EALDH1A1L3MBTL1EP300 | |
| SCHEMBL9352348 | 0.86 | ALDH1A1 (0.47) | MAPTHPGDKDM4ECYP1A2CYP3A4 | |
| SCHEMBL9352330 | 0.86 | FEN1 (0.51) | MAPTHPGDKDM4ECYP1A2CYP3A4 | |
| SCHEMBL10667933 | 0.86 | PKM (0.47) | MAPTKDM4ECYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5350755-A | Treatment of psoriasis or eczema with naphthyridine derivative | SCHERING CORPORATION (US) | 1994-09-27 | — | — | US | disclosed |
| EP-0144996-B1 | SUBSTITUTED SPIRO PYRIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THE PREPARATION OF SUCH COMPOUNDS AND COMPOSITIONS | SCHERING CORPORATION (US) | 1990-02-28 | — | — | EP | disclosed |
| US-4775524-A | PSORIASIS | SCHERING CORPORATION (US) | 1988-10-04 | — | — | US | disclosed |
| US-4652564-A | Substituted spiro pyridine derivatives as anti-allergy and antiinflammatory agents | SCHERING CORPORATION (US) | 1987-03-24 | — | — | US | disclosed |
| US-4632923-A | Substituted hetero spiro pyridine derivatives as anti-allergy and anti-inflammatory agents | SCHERING CORPORATION (US) | 1986-12-30 | — | — | US | disclosed |
| EP-0144996-A2 | Substituted spiro pyridine derivatives, pharmaceutical compositions containing them and processes for the preparation of such compounds and compositions | SCHERING CORPORATION (US) | 1985-06-19 | — | — | EP | disclosed |