Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINA6 | P08185 | 4/20 | 0.85 |
| ▸ | FNTA | P49354 | 1/20 | 0.69 |
| ▸ | FNTB | P49356 | 1/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.61 |
| ▸ | LMNA | P02545 | 6/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.61 |
| ▸ | MAPT | P10636 | 4/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.61 |
| ▸ | TSHR | P16473 | 3/20 | 0.61 |
| ▸ | SHBG | P04278 | 3/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.61 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.61 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.61 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.61 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9348241 | 1.00 | SERPINA6 (0.85) | SERPINA6FNTAFNTBSMN1; SMN2LMNA | |
| SCHEMBL18927106 | 1.00 | SERPINA6 (0.85) | SERPINA6FNTAFNTBSMN1; SMN2LMNA | |
| SCHEMBL15920543 | 0.92 | SERPINA6 (1.00) | SERPINA6FNTAFNTBSMN1; SMN2LMNA | |
| SCHEMBL14420894 | 0.92 | SERPINA6 (1.00) | SERPINA6FNTAFNTBSMN1; SMN2LMNA | |
| SCHEMBL668966 | 0.92 | SERPINA6 (1.00) | SERPINA6FNTAFNTBSMN1; SMN2LMNA | |
| SCHEMBL15904593 | 0.92 | SERPINA6 (1.00) | SERPINA6FNTAFNTBSMN1; SMN2LMNA | |
| SCHEMBL14525642 | 0.92 | SERPINA6 (1.00) | SERPINA6FNTAFNTBSMN1; SMN2LMNA | |
| SCHEMBL6347180 | 0.90 | SERPINA6 (0.84) | SERPINA6FNTAFNTBSMN1; SMN2LMNA | |
| SCHEMBL31095098 | 0.89 | SERPINA6 (0.82) | SERPINA6FNTAFNTBSMN1; SMN2LMNA | |
| SCHEMBL5497592 | 0.88 | SERPINA6 (0.80) | SERPINA6FNTAFNTBSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0427434-B1 | 11-keto or hydroxy 3,5-diene steroids as inhibitors of steroid 5-alpha-reductase | SMITHKLINE BEECHAM CORP (US) | 1994-12-14 | — | — | EP | disclosed |
| EP-0375351-B1 | Phosphonic acid substituted steroids as steroid 5alpha-reductase inhibitors | SMITHKLINE BEECHAM CORP (US) | 1994-08-31 | — | — | EP | disclosed |
| EP-0375349-B1 | Phosphinic acid substituted steroids as inhibitors of steroid 5alpha-reductase | SMITHKLINE BEECHAM CORP (US) | 1994-08-31 | — | — | EP | disclosed |
| EP-0289327-B1 | STEROID 5-ALPHA-REDUCTASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1991-12-18 | — | — | EP | disclosed |
| US-5041433-A | 11-keto or hydroxy 3,5-diene steroids as inhibitors of steriod 5-α-reductase | SMITHKLINE BEECHAM CORPORATION (US) | 1991-08-20 | — | — | US | disclosed |
| US-5026882-A | Phosphinic acid substituted steroids as inhibitors of steroid 5α-reductase | SMITHKLINE BEECHAM CORPORATION (US) | 1991-06-25 | — | — | US | disclosed |
| US-5017568-A | Enzyme inhibitors, carboxylation | SMITHKLINE BEECHAM CORPORATION (US) | 1991-05-21 | — | — | US | disclosed |
| EP-0427434-A2 | 11-keto or hydroxy 3,5-diene steroids as inhibitors of steroid 5-alpha-reductase | SMITHKLINE BEECHAM CORPORATION (US) | 1991-05-15 | — | — | EP | disclosed |
| US-4946834-A | ACRYLATE ANALOGUES OF STEROIDAL SYNTHETIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1990-08-07 | — | — | US | disclosed |
| EP-0375351-A1 | Phosphonic acid substituted steroids as steroid 5alpha-reductase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1990-06-27 | — | — | EP | disclosed |
| EP-0375349-A1 | Phosphinic acid substituted steroids as inhibitors of steroid 5alpha-reductase | SMITHKLINE BEECHAM CORPORATION (US) | 1990-06-27 | — | — | EP | disclosed |
| EP-0289327-A2 | Steroid 5-alpha-reductase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1988-11-02 | — | — | EP | disclosed |