Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.50 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.48 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.48 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.48 |
| ▸ | CES2 | O00748 | 1/20 | 0.48 |
| ▸ | CES1 | P23141 | 1/20 | 0.48 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL111650 | 0.92 | — | — | |
| SCHEMBL28253955 | 0.92 | TSHR (0.60) | ALDH1A1KMT2ATDP1MAPK1L3MBTL1 | |
| SCHEMBL4363424 | 0.90 | TSHR (0.57) | ALDH1A1KMT2ATDP1MAPK1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL38661600 | 0.90 | TSHR (0.57) | ALDH1A1KMT2ATDP1MAPK1L3MBTL1 | |
| Water SCHEMBL2348698 | 0.90 | TSHR (0.57) | ALDH1A1KMT2ATDP1MAPK1L3MBTL1 | |
| Fluoride SCHEMBL27339282 | 0.90 | TSHR (0.57) | ALDH1A1KMT2ATDP1MAPK1L3MBTL1 | |
| Ethaneperoxoic Acid SCHEMBL27833212 | 0.87 | ALDH1A1 (0.64) | ALDH1A1KMT2ATDP1MAPK1L3MBTL1 | |
| Methylamine SCHEMBL28341679 | 0.85 | IDO1 (0.54) | ALDH1A1KMT2ATDP1MAPK1L3MBTL1 | |
| Butane SCHEMBL5564092 | 0.83 | TSHR (0.50) | ALDH1A1KMT2ATDP1MAPK1L3MBTL1 | |
| Bicarbonate SCHEMBL9066694 | 0.82 | ALDH1A1 (0.58) | ALDH1A1KMT2ATDP1MAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5028720-A | 6,7-nonsubstituted and 6,7-disubstituted-3,4-dihydroxy benzopyran-2H-one compounds having antiaggregatory properties and processes for their preparation | OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 1991-07-02 | — | — | US | claimed |
| EP-4482888-A1 | POLYORGANOSILOXANE COPOLYMERS WITH ORGANIC POLYMERS | Wacker Chemie AG (DE) | 2025-01-01 | — | — | EP | disclosed |
| CN-119213071-A | Impact modified polypropylene composition, articles and method of making the same | 布拉斯科有限公司 | 2024-12-27 | — | — | CN | disclosed |
| EP-4384392-A1 | METAL-PLATED LAMINATES CONTAINING POLYORGANOSILOXANES | Wacker Chemie AG (DE) | 2024-06-19 | — | — | EP | disclosed |
| WO-2023160814-A1 | POLYORGANOSILOXANE COPOLYMERS WITH ORGANIC POLYMERS | WACKER CHEMIE AG (DE) | 2023-08-31 | — | — | WO | disclosed |
| WO-2023140263-A1 | THERMALLY EXPANDABLE MICROSPHERES, HOLLOW PARTICLES, AND USE THEREOF | 松本油脂製薬株式会社 | 2023-07-27 | — | — | WO | disclosed |
| WO-2023016649-A1 | METAL-PLATED LAMINATES CONTAINING POLYORGANOSILOXANES | WACKER CHEMIE AG (DE) | 2023-02-16 | — | — | WO | disclosed |
| WO-2022004369-A1 | MASTERBATCH FOR FOAM MOLDING AND USE THEREOF | 松本油脂製薬株式会社 | 2022-01-06 | — | — | WO | disclosed |
| CN-110734601-A | Liquid and meltable solid grade scorch-protected peroxides | 阿科玛股份有限公司 | 2020-01-31 | — | — | CN | disclosed |
| WO-2020017361-A1 | HEAT-EXPANDABLE MICROSPHERE AND USE THEREOF | 松本油脂製薬株式会社 | 2020-01-23 | — | — | WO | disclosed |
| US-5298526-A | Optically pure stereogenically labile 4-substituted-2-hydroxytetronic acids and pharmaceutical use | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 1994-03-29 | — | — | US | disclosed |
| US-5204341-A | Treating spasmodic disorders in gastro-enterology, in gynecology, in obsteretics and in urology | ROUSSEL UCLAF (FR) | 1993-04-20 | — | — | US | disclosed |
| US-5166271-A | N-substituted maleimide with vinyl chloride graft polymerized | MITSUI TOATSU CHEMICALS, INC. (JP) | 1992-11-24 | — | — | US | disclosed |
| EP-0490765-A2 | 1-Arylsulfonyl-2-pyrrolidone-derivatives, process for their preparation, new in termediates, use for medicaments and drugs containing them | ROUSSEL-UCLAF (FR) | 1992-06-17 | — | — | EP | disclosed |
| US-5095126-A | Efficient synthesis for optically pure stereogenically labile 4-substituted-2-hydroxytetronic acids | OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 1992-03-10 | — | — | US | disclosed |
| US-5028720-A | 6,7-nonsubstituted and 6,7-disubstituted-3,4-dihydroxy benzopyran-2H-one compounds having antiaggregatory properties and processes for their preparation | OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 1991-07-02 | — | — | US | disclosed |
| EP-0359464-A2 | Heat resistant polyvinyl chloride copolymer and preparation process of the copolymer | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1990-03-21 | — | — | EP | disclosed |
| US-4845121-A | Aci-reductone compounds belonging to the 6,7-disubstituted-3,4-dihydro benzopyan-2H-one class having antiaggregatory properties | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 1989-07-04 | — | — | US | disclosed |
| US-4645817-A | PHASE TRANSFER CATALYSIS; COMPLEXES | BAYER AKTIENGESELLSCHAFT (DE) | 1987-02-24 | — | — | US | disclosed |
| US-3966414-A | FREE-RADICAL SENSITIVE DYE, PEROXIDE | BIO-MEDICAL SCIENCES, INC. (US) | 1976-06-29 | — | — | US | disclosed |