Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 6/20 | 0.51 |
| ▸ | SRD5A1 | P18405 | 4/20 | 0.39 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.38 |
| ▸ | NPC1L1 | Q9UHC9 | 1/20 | 0.37 |
| ▸ | OSBP | P22059 | 1/20 | 0.35 |
| ▸ | OSBP2 | Q969R2 | 1/20 | 0.35 |
| ▸ | VDR | P11473 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9348037 | 0.84 | SRD5A2 (0.51) | SRD5A2SRD5A1GPBAR1NPC1L1OSBP | |
| SCHEMBL9822553 | 0.84 | SRD5A2 (0.59) | SRD5A2SRD5A1GPBAR1NPC1L1VDR | |
| SCHEMBL9782796 | 0.84 | SRD5A2 (0.59) | SRD5A2SRD5A1GPBAR1NPC1L1VDR | |
| SCHEMBL8151311 | 0.83 | SRD5A2 (0.71) | SRD5A2SRD5A1GPBAR1 | |
| SCHEMBL8151310 | 0.83 | SRD5A2 (0.71) | SRD5A2SRD5A1GPBAR1 | |
| SCHEMBL11246664 | 0.83 | SRD5A2 (0.48) | SRD5A2SRD5A1GPBAR1NPC1L1OSBP | |
| SCHEMBL9351737 | 0.78 | SRD5A2 (0.57) | SRD5A2SRD5A1GPBAR1 | |
| SCHEMBL9351731 | 0.78 | SRD5A2 (0.57) | SRD5A2SRD5A1GPBAR1 | |
| SCHEMBL9349296 | 0.74 | SRD5A1 (0.45) | SRD5A2SRD5A1GPBAR1NPC1L1OSBP | |
| SCHEMBL9349304 | 0.74 | SRD5A1 (0.45) | SRD5A2SRD5A1GPBAR1NPC1L1OSBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0375349-B1 | Phosphinic acid substituted steroids as inhibitors of steroid 5alpha-reductase | SMITHKLINE BEECHAM CORP (US) | 1994-08-31 | — | — | EP | disclosed |
| US-5026882-A | Phosphinic acid substituted steroids as inhibitors of steroid 5α-reductase | SMITHKLINE BEECHAM CORPORATION (US) | 1991-06-25 | — | — | US | disclosed |
| EP-0375349-A1 | Phosphinic acid substituted steroids as inhibitors of steroid 5alpha-reductase | SMITHKLINE BEECHAM CORPORATION (US) | 1990-06-27 | — | — | EP | disclosed |