Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 3/20 | 0.59 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.40 |
| ▸ | VDR | P11473 | 3/20 | 0.39 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.39 |
| ▸ | NPC1L1 | Q9UHC9 | 1/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9782796 | 1.00 | SRD5A2 (0.59) | SRD5A2SRD5A1VDRGPBAR1CYP2C9 | |
| SCHEMBL9782708 | 0.86 | SRD5A2 (0.79) | SRD5A2SRD5A1VDRGPBAR1CYP2C9 | |
| SCHEMBL10334081 | 0.86 | SRD5A2 (0.79) | SRD5A2SRD5A1VDRGPBAR1CYP2C9 | |
| SCHEMBL9782700 | 0.86 | SRD5A2 (0.79) | SRD5A2SRD5A1VDRGPBAR1CYP2C9 | |
| SCHEMBL9348037 | 0.85 | SRD5A2 (0.51) | SRD5A2SRD5A1VDRGPBAR1NPC1L1 | |
| SCHEMBL9782782 | 0.84 | SRD5A2 (0.46) | SRD5A2SRD5A1 | |
| SCHEMBL9782776 | 0.84 | SRD5A2 (0.46) | SRD5A2SRD5A1 | |
| SCHEMBL9348309 | 0.84 | SRD5A2 (0.51) | SRD5A2SRD5A1VDRGPBAR1NPC1L1 | |
| SCHEMBL11246664 | 0.82 | SRD5A2 (0.48) | SRD5A2SRD5A1VDRGPBAR1NPC1L1 | |
| SCHEMBL9822544 | 0.81 | SRD5A2 (0.47) | SRD5A2SRD5A1VDRGPBAR1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0289327-B1 | STEROID 5-ALPHA-REDUCTASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1991-12-18 | — | — | EP | disclosed |
| US-4910226-A | Estrane compound | SMITHKLINE BECKMAN CORPORATION (US) | 1990-03-20 | — | — | US | disclosed |
| EP-0289327-A2 | Steroid 5-alpha-reductase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1988-11-02 | — | — | EP | disclosed |