SCHEMBL9348371

SCHEMBL9348371

O=C(ON(c1ccccc1)c1ccccc1)ON(c1ccccc1)c1ccccc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 2/20 0.48
ATM Q13315 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
ALDH1A1 P00352 3/20 0.40
KMT2A Q03164 2/20 0.40
TSHR P16473 2/20 0.40
NPC1 O15118 1/20 0.40
POLB P06746 1/20 0.40
HTT P42858 1/20 0.40
RAB9A P51151 1/20 0.40
GLA P06280 1/20 0.40
MTNR1A P48039 1/20 0.38
MTNR1B P49286 1/20 0.38
F2 P00734 1/20 0.37
LMNA P02545 1/20 0.37
ALOX15 P16050 1/20 0.37
MEN1 O00255 1/20 0.36
CYP3A4 P08684 1/20 0.36
CYP2C9 P11712 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28581000 0.85 NPSR1 (0.48) NPSR1ATMTDP1L3MBTL1ALDH1A1
SCHEMBL28575884 0.82 SMN1; SMN2 (0.49) ALDH1A1KMT2ATSHRNPC1GLA
SCHEMBL6851360 0.81 LMNA (0.56) NPSR1TDP1ALDH1A1KMT2ATSHR
SCHEMBL4428614 0.81 NPSR1 (0.44) NPSR1ATMTDP1L3MBTL1ALDH1A1
SCHEMBL4467640 0.81 NPSR1 (0.44) NPSR1ATMTDP1L3MBTL1ALDH1A1
SCHEMBL27324937 0.79 NPSR1 (0.43) NPSR1ATMTDP1L3MBTL1ALDH1A1
SCHEMBL14693878 0.78 ATM (0.42) NPSR1ATMTDP1L3MBTL1ALDH1A1
SCHEMBL28777147 0.78 NPSR1 (0.41) NPSR1ATMTDP1L3MBTL1ALDH1A1
SCHEMBL4943809 0.76 NPSR1 (0.40) NPSR1ATMTDP1L3MBTL1ALDH1A1
SCHEMBL27564763 0.74 NPSR1 (0.39) NPSR1ATMTDP1L3MBTL1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5296602-A Condensing substituted ortho-halo- or ortho-aminobenzoic acid with meta-halo- or meta-aminoanisole, cyclizing, N-alkylating, de-O-methylating SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) 1994-03-22 US disclosed
WO-1992016509-A1 MULTISUBSTITUTED 1-HYDROXY-9-ACRIDONES WITH ANTICANCER ACTIVITY SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) 1992-10-01 WO disclosed
US-4713439-A THERMAL CYCLIZATION OF A POLYAMIDE ACID OF A DIAMINODIPHENYL CARBONATE AND TETRACARBOXYLIC ACID; HEAT AND SOLVENT RESISTANCE THE UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF THE NATIONAL AERONAUTICS AND SPACE ADMINISTRATION (US) 1987-12-15 US disclosed