SCHEMBL9348553

SCHEMBL9348553

O=C(CC(=O)c1ccccc1)Nc1ccc2[nH]ncc2c1

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 6/20 0.72
RAB9A P51151 5/20 0.72
JAK2 O60674 2/20 0.72
ROCK2 O75116 7/20 0.66
ROCK1 Q13464 7/20 0.66
ALDH1A1 P00352 1/20 0.63
MAPT P10636 1/20 0.63
HPGD P15428 1/20 0.63
ALOX12 P18054 1/20 0.63
CTNNB1 P35222 1/20 0.62
WNT3A P56704 1/20 0.62
MEN1 O00255 2/20 0.58
KMT2A Q03164 2/20 0.58
DYRK3 O43781 1/20 0.58
MAP4K4 O95819 1/20 0.58
RPS6KB1 P23443 1/20 0.58
CLK2 P49760 1/20 0.58
CSNK2A1 P68400 1/20 0.58
DYRK1A Q13627 1/20 0.58
CLK4 Q9HAZ1 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3380296 0.84 NPC1 (1.00) NPC1RAB9AJAK2ROCK2ROCK1
SCHEMBL13305111 0.82 CTNNB1 (0.84) NPC1RAB9AJAK2ROCK2ROCK1
SCHEMBL2571077 0.81 ROCK2 (0.74) NPC1RAB9AJAK2ROCK2ROCK1
SCHEMBL2569734 0.81 CTNNB1 (0.63) NPC1RAB9AJAK2ROCK2ROCK1
SCHEMBL5411112 0.80 P2RX7 (0.65) NPC1RAB9AJAK2ROCK2ROCK1
SCHEMBL17776529 0.80 ROCK2 (0.71) NPC1RAB9AJAK2ROCK2ROCK1
SCHEMBL15147870 0.80 ROCK2 (1.00) NPC1RAB9AJAK2ROCK2ROCK1
SCHEMBL4577230 0.80 ROCK2 (0.67) NPC1RAB9AJAK2ROCK2ROCK1
SCHEMBL5413153 0.79 ROCK2 (0.71) NPC1RAB9AJAK2ROCK2ROCK1
SCHEMBL2572294 0.79 ROCK2 (0.66) NPC1RAB9AJAK2ROCK2ROCK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0238271-B1 Silver halide photographic material and method of processing the same KONISHIROKU PHOTO IND (JP) 1994-08-10 EP disclosed
US-4897340-A RAPIDLY AUTOMATIC PROCESSABLE FILMS HAVING A HYDROPHILIC COLLOIDAL PROTECTIVE LAYER AND A LAYER CONTAINING CORE/SHELL OR TUBULAR GRAINS OF SILVER HALIDE; X-RAY FILMS; WEAR RESISTANCE; ANTISOILANTS KONICA CORPORATION (JP) 1990-01-30 US disclosed
EP-0316864-A2 Silver halide photographic light-sensitive material and processing method KONICA CORPORATION (JP) 1989-05-24 EP disclosed
EP-0238271-A2 Silver halide photographic material and method of processing the same KONICA CORPORATION (JP) 1987-09-23 EP disclosed
EP-0060118-B1 STABLE PHOTOGRAPHIC DEVELOPING SOLUTION CONTAINING AN INDAZOLE ANTIFOGGANT AND A LIGNOSULFONATE EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1985-02-13 EP disclosed
EP-0060118-A1 Stable photographic developing solution containing an indazole antifoggant and a lignosulfonate EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1982-09-15 EP disclosed
US-4323642-A Stable photographic developers containing an indazole antifoggant and a lignosulfonate EASTMAN KODAK COMPANY (US) 1982-04-06 US disclosed