Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Hydrochlorothiazide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 1.00 |
| ▸ | CA2 | P00918 | 5/20 | 1.00 |
| ▸ | CA1 | P00915 | 5/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 4/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 1.00 |
| ▸ | THRB | P10828 | 2/20 | 1.00 |
| ▸ | APEX1 | P27695 | 1/20 | 1.00 |
| ▸ | HTR2B | P41595 | 1/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 1/20 | 1.00 |
| ▸ | CA12 | O43570 | 5/20 | 0.70 |
| ▸ | CA9 | Q16790 | 4/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.65 |
| ▸ | CA7 | P43166 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | CA4 | P22748 | 1/20 | 0.53 |
| ▸ | CA6 | P23280 | 1/20 | 0.53 |
| ▸ | CA5A | P35218 | 1/20 | 0.53 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.53 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochlorothiazide SCHEMBL29366243 | 1.00 | LMNA (1.00) | LMNACA2CA1CYP2C9SMN1; SMN2 | |
| Hydrochlorothiazide SCHEMBL156490 | 1.00 | LMNA (1.00) | LMNACA2CA1CYP2C9SMN1; SMN2 | |
| Hydrochlorothiazide SCHEMBL27630714 | 0.99 | LMNA (0.97) | LMNACA2CA1CYP2C9SMN1; SMN2 | |
| Hydrochlorothiazide SCHEMBL9508286 | 0.99 | LMNA (0.97) | LMNACA2CA1CYP2C9SMN1; SMN2 | |
| Hydrochlorothiazide SCHEMBL27674482 | 0.99 | LMNA (0.97) | LMNACA2CA1CYP2C9SMN1; SMN2 | |
| Hydrochlorothiazide SCHEMBL1333333 | 0.99 | LMNA (0.97) | LMNACA2CA1CYP2C9SMN1; SMN2 | |
| Hydrochlorothiazide SCHEMBL10408471 | 0.99 | LMNA (0.97) | LMNACA2CA1CYP2C9SMN1; SMN2 | |
| Hydrochlorothiazide SCHEMBL10778059 | 0.99 | LMNA (0.97) | LMNACA2CA1CYP2C9SMN1; SMN2 | |
| Hydrochlorothiazide SCHEMBL27992968 | 0.99 | LMNA (0.97) | LMNACA2CA1CYP2C9SMN1; SMN2 | |
| Hydrochlorothiazide SCHEMBL5929409 | 0.99 | LMNA (0.97) | LMNACA2CA1CYP2C9SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 47795 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4747611-A1 | OPTICAL ELECTRODE ANALYTE DETECTION SYSTEM AND METHODS OF USE | Vital Biosciences Inc. (CA) | 2026-05-27 | — | — | EP | claimed |
| EP-3607938-B1 | PHARMACEUTICAL COMPOSITION | SOVIC BRKICIC LJILJANA (HR) | 2026-05-27 | — | — | EP | claimed |
| CN-122094963-A | Cardioprotective lipids and methods of use | — | 2026-05-26 | — | — | CN | claimed |
| WO-2026106917-A1 | EDIBLE TRANSMUCOSAL DRUG DELIVERY METHOD USING AN INTERMEDIATE CAPSULE AS A TEMPORARY VESSEL | BioPhysics Pharma, Inc. (US) | 2026-05-21 | — | — | WO | claimed |
| CN-122070133-A | Pharmaceutical compositions containing androgen receptor inhibitors/antagonists, methods and uses | 苏州开拓药业股份有限公司 | 2026-05-19 | — | — | CN | claimed |
| CN-121015662-B | Olmesartan medoxomil amlodipine hydrochlorothiazide three-compound preparation and preparation method and application thereof | 上海腾瑞制药股份有限公司 | 2026-05-12 | — | — | CN | claimed |
| US-12617809-B2 | Cardioprotective lipid and method of use | SIGNPATH PHARMA, INC. (US) | 2026-05-05 | — | — | US | claimed |
| WO-2026090360-A1 | FUSED PYRIMIDINE COMPOUNDS FOR TREATMENT OF TINNITUS, HEARING LOSS, AND MENIERE'S DISEASE | OVID THERAPEUTICS INC. (US) | 2026-04-30 | — | — | WO | claimed |
| EP-4731198-A1 | COMPOUNDS FOR USE IN THE TREATMENT OF NAPE-PLD RELATED DISEASES AND METHODS OF IDENTIFICATION THEREOF | Fondazione Istituto Italiano di Tecnologia (IT) | 2026-04-29 | — | — | EP | claimed |
| EP-3934654-B1 | ISTAROXIME OR ITS METABOLITE PST-3093 FOR USE AS INTRAVENOUS FORMULATION FOR THE TREATMENT OF ACUTE HEART FAILURE (AHF) | WINDTREE THERAPEUTICS INC (US) | 2026-04-29 | — | — | EP | claimed |
| EP-0012401-A1 | Carboxyalkyl dipeptide derivatives, process for preparing them and pharmaceutical composition containing them | MERCK & CO. INC. (US) | 1980-06-25 | — | — | EP | claimed |
| EP-0009657-A1 | Diuretic compositions comprising 2,4-diamino-5-(4-amino-3,5-dimethoxybenzyl)-pyrimidine and a diuretic which causes excretion of potassium and their preparation | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1980-04-16 | — | — | EP | claimed |
| US-4179503-A | DIURETICS | AMERICAN HOME PRODUCTS CORP. (US) | 1979-12-18 | — | — | US | claimed |
| US-4178374-A | SUBSTITUTED 1,2,5-THIADIAZOLE B-ADRENERGIC BLOCKING AGENT, PYRAZINE AND/OR THIAZIDE DIURETIC, TREATMENT OF HYPERTENSION | MERCK & CO., INC. (US) | 1979-12-11 | — | — | US | claimed |
| WO-1979001037-A1 | 1-HYDROXYALKANAMINE PYRANO(3,4-B)INDOLE DERIVATIVES | AMERICAN HOME PROD (US) | 1979-11-29 | — | — | WO | claimed |
| EP-0005365-A1 | Pyrano and thiopyrano (3,4-b) indole derivatives, processes for their preparation and pharmaceutical compositions containing them | AMERICAN HOME PRODUCTS CORPORATION (US) | 1979-11-14 | — | — | EP | claimed |
| US-4075335-A | HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1978-02-21 | — | — | US | claimed |
| US-4071669-A | ADDITIVES FOR PRESSURE SENSITIVE ADHESIVES AND TACKIFYING AGENTS | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 1978-01-31 | — | — | US | claimed |
| US-4029776-A | MITIGATING SECONDARY ALDOSTERONISM AND POTASSIUM DEPLETION INDUCED BY DIURETIC THERAPY | STERLING DRUG INC. (US) | 1977-06-14 | — | — | US | claimed |
| US-4022893-A | Treatment for hypertension | MOYER JOHN H | 1977-05-10 | — | — | US | claimed |