Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Hydrochlorothiazide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.97 |
| ▸ | CA2 | P00918 | 5/20 | 0.97 |
| ▸ | CA1 | P00915 | 5/20 | 0.97 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.97 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.97 |
| ▸ | THRB | P10828 | 2/20 | 0.97 |
| ▸ | APEX1 | P27695 | 1/20 | 0.97 |
| ▸ | HTR2B | P41595 | 1/20 | 0.97 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.97 |
| ▸ | CA12 | O43570 | 5/20 | 0.68 |
| ▸ | CA9 | Q16790 | 4/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | CA7 | P43166 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | CA4 | P22748 | 1/20 | 0.52 |
| ▸ | CA6 | P23280 | 1/20 | 0.52 |
| ▸ | CA5A | P35218 | 1/20 | 0.52 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.52 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochlorothiazide SCHEMBL156490 | 0.99 | LMNA (1.00) | LMNACA2CA1CYP2C9SMN1; SMN2 | |
| Hydrochlorothiazide SCHEMBL9349 | 0.99 | LMNA (1.00) | LMNACA2CA1CYP2C9SMN1; SMN2 | |
| Hydrochlorothiazide SCHEMBL29366243 | 0.99 | LMNA (1.00) | LMNACA2CA1CYP2C9SMN1; SMN2 | |
| Hydrochlorothiazide SCHEMBL27630714 | 0.97 | LMNA (0.97) | LMNACA2CA1CYP2C9SMN1; SMN2 | |
| Hydrochlorothiazide SCHEMBL27674482 | 0.97 | LMNA (0.97) | LMNACA2CA1CYP2C9SMN1; SMN2 | |
| Hydrochlorothiazide SCHEMBL10778059 | 0.97 | LMNA (0.97) | LMNACA2CA1CYP2C9SMN1; SMN2 | |
| Hydrochlorothiazide SCHEMBL10408471 | 0.97 | LMNA (0.97) | LMNACA2CA1CYP2C9SMN1; SMN2 | |
| Hydrochlorothiazide SCHEMBL1333333 | 0.97 | LMNA (0.97) | LMNACA2CA1CYP2C9SMN1; SMN2 | |
| Hydrochlorothiazide SCHEMBL27992968 | 0.97 | LMNA (0.97) | LMNACA2CA1CYP2C9SMN1; SMN2 | |
| Hydrochlorothiazide SCHEMBL5929409 | 0.97 | LMNA (0.97) | LMNACA2CA1CYP2C9SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0154009-B1 | USE OF A THIAZIDE DIURETIC FOR THE MANUFACTURE OF A NON-DIURETIC ANTIHYPERTENSIVE MEDICAMENT | Euro-Celtique S.A. (LU) | 1993-07-14 | — | — | EP | disclosed |
| US-4898729-A | Treatment of hypertension, compounds and compositions for antihypertension and diuresis | EUROCELTIQUE, S.A. (LU) | 1990-02-06 | — | — | US | disclosed |
| EP-0154009-A1 | Use of a thiazide diuretic for the manufacture of a non-diuretic antihypertensive medicament | Euro-Celtique S.A. (LU) | 1985-09-11 | — | — | EP | disclosed |