Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX4 | Q99571 | 6/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | SCN4A | P35499 | 1/20 | 0.46 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.46 |
| ▸ | CES1 | P23141 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | CES2 | O00748 | 3/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.45 |
| ▸ | DAO | P14920 | 1/20 | 0.45 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29120205 | 0.86 | MAPT (0.45) | P2RX4TSHRLMNAMAPK1SCN4A | |
| SCHEMBL29375766 | 0.82 | MAPT (0.53) | P2RX4TSHRLMNAMAPK1SCN4A | |
| SCHEMBL27566643 | 0.82 | MAPT (0.53) | P2RX4TSHRLMNAMAPK1SCN4A | |
| SCHEMBL29418986 | 0.82 | MAPT (0.53) | P2RX4TSHRLMNAMAPK1SCN4A | |
| SCHEMBL33554 | 0.82 | — | — | |
| SCHEMBL29398195 | 0.82 | — | — | |
| Acrylic Acid SCHEMBL11129651 | 0.81 | LMNA (0.50) | P2RX4TSHRLMNAMAPK1SCN4A | |
| Methacrylic Acid SCHEMBL19876935 | 0.79 | ALDH1A1 (0.44) | P2RX4TSHRLMNAMAPK1SCN4A | |
| SCHEMBL29120222 | 0.79 | MAPT (0.45) | P2RX4TSHRLMNAMAPK1SCN4A | |
| SCHEMBL8984812 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0402975-B1 | Benzocyclobutene carboxylate esters | SHELL INT RESEARCH (NL) | 1994-08-10 | — | — | EP | claimed |