SCHEMBL9350586

SCHEMBL9350586

C=C(C)C(=O)c1ccc(Sc2ccc(C(=O)C(=C)C)cc2)cc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 2/20 0.61
LMNA P02545 2/20 0.61
L3MBTL1 Q9Y468 1/20 0.61
MAPT P10636 2/20 0.57
ALDH1A1 P00352 1/20 0.53
THRA P10827 1/20 0.47
THRB P10828 1/20 0.47
MEN1 O00255 1/20 0.44
KMT2A Q03164 1/20 0.44
CES2 O00748 6/20 0.39
CES1 P23141 6/20 0.39
NR1H2 P55055 1/20 0.37
RARB P10826 1/20 0.37
RARG P13631 1/20 0.37
RXRA P19793 1/20 0.37
RXRB P28702 1/20 0.37
RXRG P48443 1/20 0.37
EGFR P00533 1/20 0.35
XBP1 P17861 1/20 0.35
ATM Q13315 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1322648 0.88 MAPT (0.80) HPGDLMNAL3MBTL1MAPTALDH1A1
SCHEMBL16850565 0.88 HPGD (0.56) HPGDLMNAL3MBTL1MAPTALDH1A1
SCHEMBL28670034 0.86 MAPT (0.71) LMNAMAPTTHRATHRBMEN1
SCHEMBL28357628 0.83 MAPT (0.53) HPGDLMNAL3MBTL1MAPTALDH1A1
SCHEMBL23900896 0.82 THRA (0.60) HPGDLMNAL3MBTL1MAPTALDH1A1
SCHEMBL24982457 0.81 MAPT (0.51) HPGDLMNAL3MBTL1MAPTALDH1A1
SCHEMBL6272776 0.77 MAPT (0.61) LMNAMAPTTHRATHRBMEN1
SCHEMBL5852775 0.77 MAPT (0.61) HPGDLMNAMAPTTHRATHRB
SCHEMBL2401025 0.77 MAPT (0.61) HPGDL3MBTL1MAPTALDH1A1THRA
SCHEMBL2816739 0.77 CES2 (0.68) HPGDLMNAMAPTALDH1A1THRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10611869-B2 Curable composition and cured product AGC Inc. (JP) 2020-04-07 US claimed
US-20190218325-A1 CURABLE COMPOSITION AND CURED PRODUCT AGC Inc. (JP) 2019-07-18 US claimed
US-10611869-B2 Curable composition and cured product AGC Inc. (JP) 2020-04-07 US disclosed
US-20190218325-A1 CURABLE COMPOSITION AND CURED PRODUCT AGC Inc. (JP) 2019-07-18 US disclosed
CN-101114036-A Optical film, production method of optical film, polarizing plate and liquid crystal display device FUJIFILM CORP (JP) 2008-01-30 CN disclosed
EP-0394495-B1 4,4'-BIS(METHACRYLOYLTHIO)DIPHENYL SULFIDE AND CURABLE COMPOSITION CONTAINING SAME SUMITOMO SEIKA CHEMICALS (JP) 1994-08-31 EP disclosed
US-5270439-A Method of producing a curable composition containing 4,4'-bis(methacryloylthio)diphenylsulfide SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) 1993-12-14 US disclosed
US-5183917-A Curable; optics, coatings, seals, adhesives, paints SHOWA DENKO K.K. (JP) 1993-02-02 US disclosed
EP-0394495-A1 4,4'-BIS(METHACRYLOYLTHIO)DIPHENYL SULFIDE AND CURABLE COMPOSITION CONTAINING SAME SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) 1990-10-31 EP disclosed