Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | PDE4A | P27815 | 8/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.46 |
| ▸ | PDE5A | O76074 | 5/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9350699 | 0.98 | SMN1; SMN2 (0.54) | SMN1; SMN2LMNAALDH1A1NPSR1PDE4A | |
| SCHEMBL9350777 | 0.82 | PDE4A (0.60) | SMN1; SMN2ALDH1A1PDE4APDE4BPDE4C | |
| SCHEMBL9350672 | 0.82 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL9350645 | 0.80 | PDE4A (0.60) | SMN1; SMN2ALDH1A1PDE4APDE4BPDE4C | |
| SCHEMBL9350631 | 0.80 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL9350756 | 0.79 | PDE4A (0.59) | SMN1; SMN2ALDH1A1PDE4APDE4BPDE4C | |
| SCHEMBL11610849 | 0.79 | SMN1; SMN2 (0.63) | SMN1; SMN2LMNAALDH1A1NPSR1PDE4A | |
| SCHEMBL10694067 | 0.79 | SMN1; SMN2 (0.67) | SMN1; SMN2LMNAALDH1A1NPSR1PDE4A | |
| SCHEMBL9350791 | 0.78 | PDE4A (0.58) | ALDH1A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9350760 | 0.77 | PDE4A (0.62) | PDE4APDE4BPDE4CPDE4DPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0369744-B1 | Xanthine derivatives, process for their preparation and pharmaceutical compositions | SMITHKLINE BEECHAM PHARMA GMBH (DE) | 1994-09-21 | — | — | EP | claimed |
| US-5321029-A | Vascular and skin disorders; bronchodilator | BEECHAM-WUELFING GMBH & CO.K.G. (DE) | 1994-06-14 | — | — | US | claimed |
| EP-0369744-A2 | Xanthine derivatives, process for their preparation and pharmaceutical compositions | SMITHKLINE BEECHAM PHARMA GmbH (DE) | 1990-05-23 | — | — | EP | claimed |
| EP-0369744-B1 | Xanthine derivatives, process for their preparation and pharmaceutical compositions | SMITHKLINE BEECHAM PHARMA GMBH (DE) | 1994-09-21 | — | — | EP | disclosed |
| US-5321029-A | Vascular and skin disorders; bronchodilator | BEECHAM-WUELFING GMBH & CO.K.G. (DE) | 1994-06-14 | — | — | US | disclosed |
| EP-0369744-A2 | Xanthine derivatives, process for their preparation and pharmaceutical compositions | SMITHKLINE BEECHAM PHARMA GmbH (DE) | 1990-05-23 | — | — | EP | disclosed |