Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 5/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14997833 | 1.00 | ELANE (0.50) | ELANEHTTPOLBAPEX1TDP1 | |
| Bromide SCHEMBL4904449 | 0.99 | ELANE (0.49) | ELANEHTTPOLBAPEX1TDP1 | |
| SCHEMBL29201825 | 0.95 | HTT (0.43) | ELANEHTTPOLBAPEX1TDP1 | |
| SCHEMBL1476595 | 0.90 | MEN1 (0.45) | HTTPOLBAPEX1TDP1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL166563 | 0.90 | MEN1 (0.45) | HTTPOLBAPEX1TDP1ALDH1A1 | |
| SCHEMBL14999554 | 0.89 | ELANE (0.52) | ELANEHTTPOLBAPEX1TDP1 | |
| Hydrochloric Acid SCHEMBL6560373 | 0.88 | POLB (0.54) | ELANEHTTPOLBAPEX1TDP1 | |
| Bromide SCHEMBL2250534 | 0.88 | MEN1 (0.44) | HTTPOLBAPEX1TDP1ALDH1A1 | |
| Fluoride Ion SCHEMBL14815797 | 0.88 | MEN1 (0.44) | HTTPOLBAPEX1TDP1ALDH1A1 | |
| Iodide SCHEMBL2252213 | 0.88 | MEN1 (0.44) | HTTPOLBAPEX1TDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0333291-B1 | Benzophenone derivatives | OCTEL CHEM LTD (GB) | 1994-08-10 | — | — | EP | disclosed |
| US-4948819-A | Benzophenone quaternary ammonium linked (meth)acrylates, photocurable and photocured products, and method of coating | WARD BLENKINSOP & COMPANY LIMITED (GB) | 1990-08-14 | — | — | US | disclosed |
| EP-0333291-A2 | Benzophenone derivatives | OCTEL CHEMICALS LIMITED (GB) | 1989-09-20 | — | — | EP | disclosed |