SCHEMBL935188

CN(C)CC(C)(C)COc1ccc2c(c1)cc(-c1cc(NC(=O)c3cnn(Cc4ccc(Cl)s4)c3)cn(COCC[Si](C)(C)C)c1=O)n2C(=O)OC(C)(C)C

nearest known ligand 0.33

Predicted protein targets (top 9)

	gene	UniProt	supporting neighbours	confidence
▸	DGAT1	O75907	1/20	0.33

▸	AURKA	O14965	2/20	0.31

▸	CCNA2	P20248	2/20	0.31

▸	CDK2	P24941	2/20	0.31

▸	TTK	P33981	2/20	0.31

▸	RPS6KA3	P51812	1/20	0.30

▸	RPS6KA2	Q15349	1/20	0.30

▸	RPS6KA1	Q15418	1/20	0.30

▸	RPS6KA6	Q9UK32	1/20	0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL935011	0.88	RPS6KA3 (0.34)	AURKACCNA2CDK2TTKRPS6KA3
SCHEMBL935596	0.87	NR1H2 (0.39)	RPS6KA3RPS6KA2RPS6KA1RPS6KA6
SCHEMBL935845	0.87	RPS6KA3 (0.33)	RPS6KA3RPS6KA2RPS6KA1RPS6KA6
SCHEMBL936942	0.84	RPS6KA3 (0.31)	RPS6KA3RPS6KA2RPS6KA1RPS6KA6
SCHEMBL1057502	0.83	RPS6KA3 (0.31)	TTKRPS6KA3RPS6KA2RPS6KA1RPS6KA6
SCHEMBL12913232	0.81	KLKB1 (0.38)	DGAT1RPS6KA3RPS6KA2RPS6KA1RPS6KA6
SCHEMBL12913263	0.80	RPS6KA3 (0.38)	RPS6KA3RPS6KA2RPS6KA1RPS6KA6
SCHEMBL951107	0.80	RPS6KA2 (0.35)	DGAT1RPS6KA3RPS6KA2RPS6KA1RPS6KA6
SCHEMBL935471	0.79	RPS6KA3 (0.45)	RPS6KA3RPS6KA2RPS6KA1RPS6KA6
SCHEMBL947809	0.79	RPS6KA2 (0.35)	RPS6KA3RPS6KA2RPS6KA1RPS6KA6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2011010083-A1	INDOLYL-PYRIDONE DERIVATIVES	VERNALIS (R & D) LTD (GB)	2011-01-27	—	—	WO	disclosed