Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.34 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.34 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.34 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.34 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.31 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.31 |
| ▸ | TTK | P33981 | 3/20 | 0.31 |
| ▸ | SCD | O00767 | 2/20 | 0.31 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 2/20 | 0.30 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.30 |
| ▸ | CDK2 | P24941 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL935596 | 0.93 | NR1H2 (0.39) | RPS6KA3RPS6KA2RPS6KA1RPS6KA6NR1H2 | |
| SCHEMBL935845 | 0.92 | RPS6KA3 (0.33) | RPS6KA3RPS6KA2RPS6KA1RPS6KA6KLKB1 | |
| SCHEMBL950118 | 0.90 | RPS6KA3 (0.37) | RPS6KA3RPS6KA2RPS6KA1RPS6KA6KLKB1 | |
| SCHEMBL936942 | 0.90 | RPS6KA3 (0.31) | RPS6KA3RPS6KA2RPS6KA1RPS6KA6 | |
| SCHEMBL1057502 | 0.89 | RPS6KA3 (0.31) | RPS6KA3RPS6KA2RPS6KA1RPS6KA6TTK | |
| SCHEMBL952270 | 0.89 | RPS6KA3 (0.36) | RPS6KA3RPS6KA2RPS6KA1RPS6KA6KLKB1 | |
| SCHEMBL935188 | 0.88 | DGAT1 (0.33) | RPS6KA3RPS6KA2RPS6KA1RPS6KA6TTK | |
| SCHEMBL12913263 | 0.86 | RPS6KA3 (0.38) | RPS6KA3RPS6KA2RPS6KA1RPS6KA6KLKB1 | |
| SCHEMBL935471 | 0.84 | RPS6KA3 (0.45) | RPS6KA3RPS6KA2RPS6KA1RPS6KA6NR1H2 | |
| SCHEMBL12913225 | 0.84 | RPS6KA3 (0.37) | RPS6KA3RPS6KA2RPS6KA1RPS6KA6KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011010083-A1 | INDOLYL-PYRIDONE DERIVATIVES | VERNALIS (R & D) LTD (GB) | 2011-01-27 | — | — | WO | disclosed |