Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 5/20 | 0.74 |
| ▸ | MAP2K1 | Q02750 | 4/20 | 0.74 |
| ▸ | BTK | Q06187 | 4/20 | 0.74 |
| ▸ | JAK3 | P52333 | 7/20 | 0.71 |
| ▸ | EGFR | P00533 | 5/20 | 0.71 |
| ▸ | JAK2 | O60674 | 1/20 | 0.71 |
| ▸ | BLK | P51451 | 1/20 | 0.71 |
| ▸ | BMX | P51813 | 1/20 | 0.71 |
| ▸ | SRC | P12931 | 3/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.66 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.66 |
| ▸ | FLT3 | P36888 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL93523 | 1.00 | MAP3K7 (0.74) | MAP3K7MAP2K1BTKJAK3EGFR | |
| SCHEMBL29352639 | 1.00 | MAP3K7 (0.74) | MAP3K7MAP2K1BTKJAK3EGFR | |
| SCHEMBL10127876 | 0.88 | JAK3 (0.80) | BTKJAK3EGFRJAK2BLK | |
| SCHEMBL28980968 | 0.87 | BTK (0.80) | MAP3K7MAP2K1BTKJAK3EGFR | |
| SCHEMBL31684778 | 0.87 | BTK (0.80) | MAP3K7MAP2K1BTKJAK3EGFR | |
| SCHEMBL22604799 | 0.85 | BTK (0.62) | MAP3K7MAP2K1BTKJAK3EGFR | |
| SCHEMBL10127962 | 0.85 | BTK (1.00) | MAP3K7MAP2K1BTKJAK3EGFR | |
| SCHEMBL22604617 | 0.85 | EGFR (0.59) | MAP3K7MAP2K1BTKJAK3EGFR | |
| SCHEMBL14914404 | 0.84 | EGFR (0.70) | MAP3K7MAP2K1BTKJAK3EGFR | |
| SCHEMBL28980965 | 0.83 | MAP3K7 (0.81) | MAP3K7MAP2K1BTKJAK3EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4330224-A1 | PCNA INHIBITORS AND EGFR INHIBITORS FOR CANCER TREATMENT | City of Hope (US) | 2024-03-06 | — | — | EP | disclosed |