Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 3/20 | 0.74 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.74 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.74 |
| ▸ | LMNA | P02545 | 2/20 | 0.74 |
| ▸ | BLM | P54132 | 2/20 | 0.74 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.74 |
| ▸ | TSHR | P16473 | 1/20 | 0.74 |
| ▸ | RAB9A | P51151 | 1/20 | 0.74 |
| ▸ | MEN1 | O00255 | 1/20 | 0.74 |
| ▸ | THRB | P10828 | 1/20 | 0.74 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.74 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.39 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.39 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.39 |
| ▸ | GLI1 | P08151 | 1/20 | 0.37 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9352608 | 1.00 | CYP2D6 (0.74) | CYP2D6ALOX15CYP1A2LMNABLM | |
| SCHEMBL9352591 | 1.00 | CYP2D6 (0.74) | CYP2D6ALOX15CYP1A2LMNABLM | |
| Ethane SCHEMBL6051635 | 0.95 | CYP2D6 (0.67) | CYP2D6ALOX15CYP1A2LMNABLM | |
| SCHEMBL9352353 | 0.89 | CYP2D6 (0.53) | CYP2D6ALOX15CYP1A2LMNABLM | |
| SCHEMBL9352345 | 0.89 | CYP2D6 (0.53) | CYP2D6ALOX15CYP1A2LMNABLM | |
| SCHEMBL1321720 | 0.86 | ALOX15 (1.00) | CYP2D6ALOX15CYP1A2LMNABLM | |
| SCHEMBL179769 | 0.86 | ALOX15 (1.00) | CYP2D6ALOX15CYP1A2LMNABLM | |
| SCHEMBL179767 | 0.86 | ALOX15 (1.00) | CYP2D6ALOX15CYP1A2LMNABLM | |
| SCHEMBL6745739 | 0.86 | ALOX15 (1.00) | CYP2D6ALOX15CYP1A2LMNABLM | |
| SCHEMBL179768 | 0.86 | ALOX15 (1.00) | CYP2D6ALOX15CYP1A2LMNABLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0299513-B1 | Azetidine derivatives, compositions and their use | FIDIA GEORGETOWN INST (US) | 1994-10-05 | — | — | EP | disclosed |
| US-4990504-A | Modulate excitatory amino acid receptor system | FIDIA-GEORGETOWN INSTITUTE FOR THE NEUROSCIENCES (US) | 1991-02-05 | — | — | US | disclosed |
| US-4946839-A | ALZHEIMER'S DISEASE | FIDIA-GEORGETOWN INSTITUTE FOR THE NEUROSCIENCES (US) | 1990-08-07 | — | — | US | disclosed |
| EP-0299513-A1 | Azetidine derivatives, compositions and their use | FIDIA-GEORGETOWN INSTITUTE FOR THE NEUROSCIENCES (US) | 1989-01-18 | — | — | EP | disclosed |