SCHEMBL179767

SCHEMBL179767

O=C(O)[C@@H]1C[C@@H](C(=O)O)N1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 4/20 1.00
CYP1A2 P05177 4/20 1.00
CYP2D6 P10635 3/20 1.00
CYP2C19 P33261 3/20 1.00
LMNA P02545 2/20 1.00
BLM P54132 2/20 1.00
TSHR P16473 2/20 1.00
PMP22 Q01453 2/20 1.00
MEN1 O00255 2/20 1.00
THRB P10828 2/20 1.00
KMT2A Q03164 2/20 1.00
RAB9A P51151 1/20 1.00
SLC1A3 P43003 1/20 0.48
SLC1A2 P43004 1/20 0.48
SLC1A1 P43005 1/20 0.48
EGLN1 Q9GZT9 1/20 0.40
GABRR1 P24046 1/20 0.38
CAD P27708 1/20 0.37
GRM2 Q14416 1/20 0.36
GRM3 Q14832 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL179769 1.00 ALOX15 (1.00) ALOX15CYP1A2CYP2D6CYP2C19LMNA
SCHEMBL6745739 1.00 ALOX15 (1.00) ALOX15CYP1A2CYP2D6CYP2C19LMNA
SCHEMBL179768 1.00 ALOX15 (1.00) ALOX15CYP1A2CYP2D6CYP2C19LMNA
SCHEMBL1321720 1.00 ALOX15 (1.00) ALOX15CYP1A2CYP2D6CYP2C19LMNA
SCHEMBL28565982 0.88 CYP2D6 (0.78) ALOX15CYP1A2CYP2D6CYP2C19LMNA
SCHEMBL9352591 0.86 CYP2D6 (0.74) ALOX15CYP1A2CYP2D6CYP2C19LMNA
SCHEMBL9352602 0.86 CYP2D6 (0.74) ALOX15CYP1A2CYP2D6CYP2C19LMNA
SCHEMBL9352608 0.86 CYP2D6 (0.74) ALOX15CYP1A2CYP2D6CYP2C19LMNA
SCHEMBL13430442 0.84
SCHEMBL23421119 0.83 CYP2C19 (0.71) ALOX15CYP1A2CYP2D6CYP2C19LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 122 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8968711-B2 Cosmetic or dermatological composition comprising a polymer bearing junction groups, and cosmetic treatment process L'OREAL (FR) 2015-03-03 US claimed
US-20110263652-A1 Treatment and/or Prevention of Inner Ear Conditions by Modulation of a Metabotropic Glutamate Receptor HOUSE EAR INSTITUTE (US) 2011-10-27 US claimed
EP-2344151-A2 TREATMENT AND/OR PREVENTION OF INNER EAR CONDITIONS BY MODULATION OF A METABOTROPIC GLUTAMATE RECEPTOR HOUSE EAR INSTITUTE (US) 2011-07-20 EP claimed
US-20100272660-A1 COSMETIC OR PHARMACEUTICAL COMPOSITION COMPRISING A POLYCONDENSATE, THE SAID POLYCONDENSATE AND METHOD OF COSMETIC TREATMENT L'OREAL (FR) 2010-10-28 US claimed
US-20100239509-A1 COSMETIC OR DERMATOLOGICAL COMPOSITION COMPRISING A POLYMER BEARING JUNCTION GROUPS, AND COSMETIC TREATMENT PROCESS L'OREAL (FR) 2010-09-23 US claimed
WO-2010048095-A2 TREATMENT AND/OR PREVENTION OF INNER EAR CONDITIONS BY MODULATION OF A METABOTROPIC GLUTAMATE RECEPTOR HOUSE EAR INSTITUTE (US) 2010-04-29 WO claimed
EP-4204100-A1 HAIR LIGHTENING COMPOSITIONS PROVIDING DAMAGE PROTECTION AND SENSORIAL BENEFITS AND METHODS OF USE L'OREAL (FR) 2023-07-05 EP disclosed
CN-116322616-A Hair lightening compositions providing damage protection and sensory benefits and methods of use 欧莱雅 2023-06-23 CN disclosed
US-11559474-B2 Hair lightening compositions and methods of use L'OREAL (FR) 2023-01-24 US disclosed
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed
WO-2022047081-A1 HAIR LIGHTENING COMPOSITIONS PROVIDING DAMAGE PROTECTION AND SENSORIAL BENEFITS AND METHODS OF USE HENRY DEREK (US) 2022-03-03 WO disclosed
WO-2018119500-A1 VISCOELASTIC COSMETIC COMPOSITIONS L'OREAL (FR) 2018-07-05 WO disclosed
US-9173864-B2 Treatment and/or prevention of inner ear conditions by modulation of a metabotropic glutamate receptor HOUSE EAR INSTITUTE (US) 2015-11-03 US disclosed
WO-2001068137-A2 COMPOSITIONS FOR REGULATING MEMORY CONSOLIDATION BROWN UNIVERSITY RESEARCH FOUNDATION (US) 2001-09-20 WO disclosed
EP-1091958-A1 SALTS OF PAROXETINE SMITHKLINE BEECHAM PLC (GB) 2001-04-18 EP disclosed
WO-2000001692-A1 SALTS OF PAROXETINE SMITHKLINE BEECHAM PLC (GB) 2000-01-13 WO disclosed
EP-0299513-B1 Azetidine derivatives, compositions and their use FIDIA GEORGETOWN INST (US) 1994-10-05 EP disclosed
US-4990504-A Modulate excitatory amino acid receptor system FIDIA-GEORGETOWN INSTITUTE FOR THE NEUROSCIENCES (US) 1991-02-05 US disclosed
US-4946839-A ALZHEIMER'S DISEASE FIDIA-GEORGETOWN INSTITUTE FOR THE NEUROSCIENCES (US) 1990-08-07 US disclosed
EP-0299513-A1 Azetidine derivatives, compositions and their use FIDIA-GEORGETOWN INSTITUTE FOR THE NEUROSCIENCES (US) 1989-01-18 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100239509-A1 COSMETIC OR DERMATOLOGICAL COMPOSITION COMPRISING A POLYMER BEARING JUNCTION GROUPS, AND COSMETIC TREATMENT PROCESS CUTA, SUCLG1, KRT18 ALOX15 914/4885CYP1A2 3261/4885CYP2D6 3808/4885
US-20100272660-A1 COSMETIC OR PHARMACEUTICAL COMPOSITION COMPRISING A POLYCONDENSATE, THE SAID POLYCONDENSATE AND METHOD OF COSMETIC TREATMENT ACMSD, CUTA, PCCA ALOX15 383/4885CYP1A2 1104/4885CYP2D6 2307/4885
US-11559474-B2 Hair lightening compositions and methods of use TYR, ALAD, CYBA ALOX15 1704/4885CYP1A2 4124/4885CYP2D6 4408/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.