Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Promethazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 5/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 8/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 8/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 8/20 | 0.52 |
| ▸ | DRD3 | P35462 | 8/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 7/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 6/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.52 |
| ▸ | DRD1 | P21728 | 6/20 | 0.52 |
| ▸ | HTR1A | P08908 | 6/20 | 0.52 |
| ▸ | LMNA | P02545 | 5/20 | 0.52 |
| ▸ | CHRM3 | P20309 | 5/20 | 0.52 |
| ▸ | HTR2A | P28223 | 5/20 | 0.52 |
| ▸ | HTR2C | P28335 | 5/20 | 0.52 |
| ▸ | HTR2B | P41595 | 5/20 | 0.52 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.52 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Promethazine SCHEMBL21518122 | 0.88 | LMNA (0.67) | CHRM2CHRM1OPRM1DRD3KCNH2 | |
| Promethazine SCHEMBL6241690 | 0.83 | CHRM2 (0.62) | CHRM2CHRM1OPRM1DRD3KCNH2 | |
| Isothipendyl SCHEMBL28086235 | 0.79 | KMT2A (0.72) | CHRM2CHRM1OPRM1DRD3KCNH2 | |
| Chlorcyclizine SCHEMBL17784319 | 0.72 | CHRM2 (0.63) | CHRM2CHRM1OPRM1DRD3KCNH2 | |
| Promethazine SCHEMBL26777 | 0.72 | CYP2D6 (1.00) | CHRM2CHRM1OPRM1DRD3KCNH2 | |
| Promethazine SCHEMBL29372077 | 0.72 | CYP2D6 (1.00) | CHRM2CHRM1OPRM1DRD3KCNH2 | |
| (S)-Promethazine SCHEMBL2900853 | 0.72 | CYP2D6 (1.00) | CHRM2CHRM1OPRM1DRD3KCNH2 | |
| Promethazine SCHEMBL4700 | 0.72 | CYP2D6 (1.00) | CHRM2CHRM1OPRM1DRD3KCNH2 | |
| Promethazine SCHEMBL6271812 | 0.71 | CYP2D6 (0.76) | CHRM2CHRM1OPRM1DRD3KCNH2 | |
| Promethazine SCHEMBL2962420 | 0.71 | LMNA (1.00) | CHRM2CHRM1OPRM1DRD3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618796-A1 | ALLEVIATING OR PREVENTION OF MIGRAINE HEADACHE ONSET WITH MAST CELL DEGRANULATION BLOCKING AGENTS | KOS PHARMACEUTICALS, INC. (US) | 1994-10-12 | — | — | EP | disclosed |
| WO-1993012773-A1 | ALLEVIATING OR PREVENTION OF MIGRAINE HEADACHE ONSET WITH MAST CELL DEGRANULATION BLOCKING AGENTS | KOS PHARMACEUTICALS, INC. (US) | 1993-07-08 | — | — | WO | disclosed |