Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Promethazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 3/20 | 0.97 |
| ▸ | LMNA | P02545 | 4/20 | 1.00 |
| ▸ | MAPT | P10636 | 3/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 3/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 3/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 3/20 | 1.00 |
| ▸ | GFER | P55789 | 3/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 2/20 | 1.00 |
| ▸ | GMNN | O75496 | 1/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.97 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.97 |
| ▸ | HTR1A | P08908 | 6/20 | 0.97 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.97 |
| ▸ | ADRA1A | P35348 | 6/20 | 0.97 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.97 |
| ▸ | DRD3 | P35462 | 6/20 | 0.97 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.97 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Promethazine SCHEMBL5501515 | 1.00 | LMNA (1.00) | LMNAMAPTSMN1; SMN2MAPK1HIF1A | |
| Promethazine SCHEMBL29390401 | 1.00 | LMNA (1.00) | LMNAMAPTSMN1; SMN2MAPK1HIF1A | |
| Promethazine SCHEMBL5425141 | 1.00 | LMNA (1.00) | LMNAMAPTSMN1; SMN2MAPK1HIF1A | |
| Promethazine SCHEMBL27559626 | 1.00 | LMNA (1.00) | LMNAMAPTSMN1; SMN2MAPK1HIF1A | |
| Promethazine SCHEMBL41904 | 1.00 | LMNA (1.00) | LMNAMAPTSMN1; SMN2MAPK1HIF1A | |
| Promethazine SCHEMBL3991025 | 0.98 | LMNA (0.97) | LMNAMAPTSMN1; SMN2MAPK1HIF1A | |
| (S)-Promethazine SCHEMBL2900853 | 0.98 | CYP2D6 (1.00) | LMNAMAPTSMN1; SMN2MAPK1HIF1A | |
| Promethazine SCHEMBL29372077 | 0.98 | CYP2D6 (1.00) | LMNAMAPTSMN1; SMN2MAPK1HIF1A | |
| Promethazine SCHEMBL26777 | 0.98 | CYP2D6 (1.00) | LMNAMAPTSMN1; SMN2MAPK1HIF1A | |
| Promethazine SCHEMBL4700 | 0.98 | CYP2D6 (1.00) | LMNAMAPTSMN1; SMN2MAPK1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 68 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2002256-B1 | REFERENCE CONTROL COMPOSITION CONTAINING A NUCLEATED RED BLOOD CELL COMPONENT MADE OF NON-NUCLEATED BLOOD CELLS | BECKMAN COULTER INC (US) | 2017-10-18 | — | — | EP | disclosed |
| EP-2702414-B1 | HEMATOLOGY CONTROL COMPOSITIONS WITH EXTENDED STABILITY | BECKMAN COULTER INC (US) | 2015-07-08 | — | — | EP | disclosed |
| EP-2082224-B1 | HEMATOLOGY LINEARITY CONTROL COMPOSITION SYSTEM AND METHOD OF USE | BECKMAN COULTER INC (US) | 2015-05-13 | — | — | EP | disclosed |
| EP-1668353-B1 | REFERENCE CONTROL FOR OPTICAL MEASUREMENT OF NUCLEATED RED BLOOD CELLS OF A BLOOD SAMPLE | BECKMAN COULTER INC (US) | 2015-03-18 | — | — | EP | disclosed |
| US-20140051063-A1 | HEMATOLOGY CONTROL COMPOSITIONS WITH EXTENDED STABILITY | BECKMAN COULTER, INC. (US) | 2014-02-20 | — | — | US | disclosed |
| CN-101535804-B | Hematology linearity control compositions, systems, and methods of use | BECKMAN COULTER INC | 2013-04-24 | — | — | CN | disclosed |
| EP-1766045-B1 | HEMATOLOGY REFERENCE CONTROL CONTAINING AN IMMATURE GRANULOCYTE COMPONENT | BECKMAN COULTER INC (US) | 2010-12-01 | — | — | EP | disclosed |
| US-7754487-B2 | Hematology linearity control composition, system and method of use | BECKMAN COULTER, INC. (US) | 2010-07-13 | — | — | US | disclosed |
| EP-2082224-A2 | HEMATOLOGY LINEARITY CONTROL COMPOSITION SYSTEM AND METHOD OF USE | Beckman Coulter, Inc. (US) | 2009-07-29 | — | — | EP | disclosed |
| EP-1682865-A4 | METHOD OF USING A REFERENCE CONTROL COMPOSITION FOR MEASUREMENT OF NUCLEATED RED BLOOD CELLS | BECKMAN COULTER INC (US) | 2009-03-18 | — | — | EP | disclosed |
| US-5320964-A | Hematology control composition including leukocyte analogs; and methods for their preparation and use | COULTER CORPORATION (US) | 1994-06-14 | — | — | US | disclosed |
| WO-1993017329-A1 | SUSPENSION MEDIA FOR HEMATOLOGICAL COMPOSITION AND METHOD FOR ITS USE | COULTER CORPORATION (US) | 1993-09-02 | — | — | WO | disclosed |
| WO-1993017330-A1 | HEMATOLOGY CONTROL COMPOSITION FOR LEUKOCYTE ANALOGS; AND METHODS FOR THEIR PREPARATION AND USE | COULTER CORPORATION (US) | 1993-09-02 | — | — | WO | disclosed |
| EP-0181393-B1 | HEMATOLOGY CONTROL COMPOSITIONS FOR THREE POPULATIONS OF LEUKOCYTES, AND METHODS FOR THEIR PREPARATION AND USE IN WHOLE BLOOD CONTROL SYSTEMS | COULTER CORPORATION (US) | 1992-09-09 | — | — | EP | disclosed |
| EP-0181393-A4 | HEMATOLOGY CONTROL COMPOSITIONS FOR THREE POPULATIONS OF LEUKOCYTES, AND METHODS FOR THEIR PREPARATION AND USE IN WHOLE BLOOD CONTROL SYSTEMS. | COULTER ELECTRONICS (US) | 1988-09-07 | — | — | EP | disclosed |
| US-4704364-A | CALIBRATION | COULTER ELECTRONICS, INC. (US) | 1987-11-03 | — | — | US | disclosed |
| EP-0181393-A1 | HEMATOLOGY CONTROL COMPOSITIONS FOR THREE POPULATIONS OF LEUKOCYTES, AND METHODS FOR THEIR PREPARATION AND USE IN WHOLE BLOOD CONTROL SYSTEMS. | COULTER ELECTRONICS (US) | 1986-05-21 | — | — | EP | disclosed |
| WO-1985005450-A1 | HEMATOLOGY CONTROL COMPOSITIONS FOR THREE POPULATIONS OF LEUKOCYTES: AND METHODS FOR THEIR PREPARATION AND USE IN WHOLE BLOOD CONTROL SYSTEMS | COULTER ELECTRONICS, INC. (US) | 1985-12-05 | — | — | WO | disclosed |
| US-4358394-A | FOR DEVICES USING ELECTRONIC MEANS FOR WHOLE BLOOD DETERMINATIONS | COULTER ELECTRONICS, INC. (US) | 1982-11-09 | — | — | US | disclosed |
| US-4299726-A | Process for preparing whole blood reference controls having long term stability, preconditioning diluent and media therefor | COULTER ELECTRONICS, INC. (US) | 1981-11-10 | — | — | US | disclosed |