Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 4/20 | 0.47 |
| ▸ | SLC6A2 known ✓ | P23975 | 7/20 | 0.45 |
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.45 |
| ▸ | KCNH2 known ✓ | Q12809 | 2/20 | 0.45 |
| ▸ | SLC6A4 known ✓ | P31645 | 5/20 | 0.43 |
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.41 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.41 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.41 |
| ▸ | HTR2B known ✓ | P41595 | 1/20 | 0.41 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.45 |
| ▸ | DRD1 | P21728 | 2/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.45 |
| ▸ | DRD3 | P35462 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9353352 | 0.96 | HRH1 (0.44) | HRH1SLC6A2SLC6A3CHRM2ADRA2A | |
| Fumaric Acid SCHEMBL9353367 | 0.96 | HRH1 (0.44) | HRH1SLC6A2SLC6A3CHRM2ADRA2A | |
| SCHEMBL9352969 | 0.89 | DRD3 (0.54) | HRH1SLC6A2SLC6A3CHRM2ADRA2A | |
| Fumaric Acid SCHEMBL9353458 | 0.88 | HRH1 (0.48) | HRH1SLC6A2SLC6A3CHRM2ADRA2A | |
| Fumaric Acid SCHEMBL9356759 | 0.87 | SLC6A2 (0.51) | HRH1SLC6A2SLC6A3CHRM2ADRA2A | |
| Fumaric Acid SCHEMBL9352891 | 0.87 | HRH1 (0.50) | HRH1SLC6A2SLC6A3CHRM2ADRA2A | |
| Fumaric Acid SCHEMBL9353001 | 0.85 | HRH1 (0.48) | HRH1SLC6A2SLC6A3CHRM2ADRA2A | |
| Fumaric Acid SCHEMBL9353039 | 0.85 | HRH1 (0.48) | HRH1SLC6A2SLC6A3CHRM2ADRA2A | |
| Maleic Acid SCHEMBL9353012 | 0.84 | SLC6A3 (0.68) | HRH1SLC6A2SLC6A3CHRM2ADRA2A | |
| Acetic Acid SCHEMBL2472607 | 0.84 | SLC6A2 (0.54) | HRH1SLC6A2SLC6A3CHRM2ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0399414-B1 | Piperidine derivative, method for preparation thereof, and a pharmaceutical composition comprising the same | HOKURIKU PHARMACEUTICAL (JP) | 1994-09-21 | — | — | EP | disclosed |
| US-5153207-A | Antihistamine and antiallergic agent | HOKURIKU PHARMACEUTICAL CO., LTD. (JP) | 1992-10-06 | — | — | US | disclosed |
| EP-0399414-A1 | Piperidine derivative, method for preparation thereof, and a pharmaceutical composition comprising the same | HOKURIKU PHARMACEUTICAL CO., LTD. (JP) | 1990-11-28 | — | — | EP | disclosed |