Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.47 |
| ▸ | ATR | Q13535 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | PRKDC | P78527 | 3/20 | 0.44 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2581392 | 0.81 | MAPT (0.51) | ATRNPC1RAB9APRKDCTLR9 | |
| SCHEMBL1328805 | 0.79 | ADORA2A (0.42) | AURKAAURKBADORA2AATRNPC1 | |
| SCHEMBL5959065 | 0.78 | NPC1 (0.54) | ATRNPC1RAB9AHPGD | |
| SCHEMBL3459860 | 0.78 | ATR (0.46) | ATRPRKDCTLR9 | |
| SCHEMBL12489014 | 0.76 | ATR (0.56) | AURKAADORA2AATRNPC1RAB9A | |
| SCHEMBL29519952 | 0.76 | ATR (0.56) | AURKAADORA2AATRNPC1RAB9A | |
| SCHEMBL27544429 | 0.75 | ATR (0.50) | AURKAAURKBATRPRKDC | |
| SCHEMBL11221248 | 0.74 | MAPKAPK2 (0.43) | AURKAAURKBADORA2ASMN1; SMN2CYP1A2 | |
| SCHEMBL6701248 | 0.73 | ATR (0.66) | ATRPRKDCTLR9 | |
| SCHEMBL32688927 | 0.73 | ATR (0.66) | ATRPRKDCTLR9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2454261-B1 | IMIDAZO[1,2-ALPHA]PYRAZIN-3(7H)-ONE DERIVATIVES BEARING A NEW ELECTRON-RICH STRUCTURE | UNIV SIENA (IT) | 2014-11-19 | — | — | EP | disclosed |
| US-8546147-B2 | Imidazo[1,2-α]pyrazin-3(7H)-one derivatives bearing a new electron-rich structure | UNIVERSITA DEGLI STUDI DI SIENA (IT) | 2013-10-01 | — | — | US | disclosed |
| US-20120171703-A1 | IMIDAZO[1,2-ALPHA]PYRAZIN-3(7H)-ONE DERIVATIVES BEARING A NEW ELECTRON-RICH STRUCTURE | UNIVERSITÁ DEGLI STUDI DI SIENA (IT) | 2012-07-05 | — | — | US | disclosed |
| EP-2454261-A1 | IMIDAZO[1,2-ALPHA]PYRAZIN-3(7H)-ONE DERIVATIVES BEARING A NEW ELECTRON-RICH STRUCTURE | Universita Degli Studi di Siena (IT) | 2012-05-23 | — | — | EP | disclosed |
| WO-2011007314-A1 | IMIDAZO[1,2-α]PYRAZIN-3(7H)-ONE DERIVATIVES BEARING A NEW ELECTRON-RICH STRUCTURE | UNIVERSITÀ DEGLI STUDI DI SIENA (IT) | 2011-01-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120171703-A1 | IMIDAZO[1,2-ALPHA]PYRAZIN-3(7H)-ONE DERIVATIVES BEARING A NEW ELECTRON-RICH STRUCTURE | GLB1, NDUFV1, IK | AURKA 3009/4885AURKB 3171/4885ADORA2A 3380/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.