Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.46 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.42 |
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
| ▸ | CCND1 | P24385 | 1/20 | 0.42 |
| ▸ | CDK9 | P50750 | 1/20 | 0.42 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.42 |
| ▸ | CDK11A | Q9UQ88 | 1/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17478686 | 0.86 | PIM1 (0.56) | KDM4EHSD17B10PIM1PIM3CDK9 | |
| SCHEMBL18607846 | 0.84 | PIM1 (0.58) | KDM4EALDH1A1HSD17B10PIM1PIM3 | |
| SCHEMBL15408226 | 0.83 | LMNA (0.54) | KDM4EALDH1A1HSD17B10HTT | |
| SCHEMBL944622 | 0.82 | POLB (0.51) | KDM4EALDH1A1HSD17B10PIM1PIM3 | |
| SCHEMBL30263296 | 0.82 | HTR2A (0.54) | KDM4EALDH1A1PIM1PIM3PRKCQ | |
| SCHEMBL25411523 | 0.82 | HTR2A (0.54) | KDM4EALDH1A1PIM1PIM3PRKCQ | |
| SCHEMBL29402590 | 0.82 | MEN1 (0.46) | ALDH1A1HSD17B10PIM1PIM3 | |
| Hydrochloric Acid SCHEMBL30782681 | 0.81 | HTR2A (0.52) | KDM4EALDH1A1PIM1PIM3PRKCQ | |
| SCHEMBL4554733 | 0.79 | KDM4E (0.48) | KDM4EALDH1A1HSD17B10ADRA2CHRH4 | |
| SCHEMBL15408382 | 0.76 | PRMT5 (0.40) | CHIAPIM1PIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2454250-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | Gilead Sciences, Inc. (US) | 2012-05-23 | — | — | EP | claimed |
| WO-2011008709-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2011-01-20 | — | — | WO | claimed |