Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.36 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29889279 | 0.82 | LRRK2 (0.43) | KDM4EALDH1A1HSD17B10LRRK2HTT | |
| SCHEMBL935378 | 0.79 | KDM4E (0.48) | KDM4EALDH1A1HSD17B10ADRA2CHTT | |
| SCHEMBL30349531 | 0.77 | PDE10A (0.46) | LRRK2CDK8 | |
| SCHEMBL31302366 | 0.76 | ADRA2C (0.49) | KDM4EALDH1A1HSD17B10CYP3A4ADRA2C | |
| SCHEMBL31005773 | 0.73 | CYP3A4 (0.52) | KDM4EALDH1A1HSD17B10CYP3A4CHEK1 | |
| SCHEMBL31330940 | 0.71 | — | — | |
| SCHEMBL17061682 | 0.70 | CYP3A4 (0.49) | KDM4EALDH1A1HSD17B10CYP3A4CHEK1 | |
| SCHEMBL31302397 | 0.69 | MEN1 (0.48) | KDM4EALDH1A1HSD17B10GLAMAPT | |
| SCHEMBL28309038 | 0.69 | SIRT3 (0.38) | KDM4EALDH1A1HSD17B10PARP1MAPT | |
| SCHEMBL3081421 | 0.68 | NPC1 (0.70) | KDM4EALDH1A1HSD17B10ADRA2CHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125748-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | AstraZeneca AB (SE) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008075068-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |