Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 8/20 | 0.64 |
| ▸ | ABCB1 | P08183 | 7/20 | 0.57 |
| ▸ | KCNE1 | P15382 | 4/20 | 0.53 |
| ▸ | KCNQ1 | P51787 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | KCND3 | Q9UK17 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10888269 | 0.85 | ABCC9 (0.67) | ABCC9ABCB1KCNE1KCNQ1MEN1 | |
| SCHEMBL9765369 | 0.85 | ABCC9 (0.56) | ABCC9ABCB1KCNE1KCNQ1 | |
| SCHEMBL9765368 | 0.85 | ABCC9 (0.56) | ABCC9ABCB1KCNE1KCNQ1 | |
| SCHEMBL9765379 | 0.85 | ABCC9 (0.56) | ABCC9ABCB1KCNE1KCNQ1 | |
| SCHEMBL9354137 | 0.84 | ABCC9 (0.73) | ABCC9ABCB1 | |
| SCHEMBL10885395 | 0.83 | ABCC9 (0.72) | ABCC9ABCB1 | |
| SCHEMBL9273381 | 0.82 | ABCC9 (0.78) | ABCC9ABCB1 | |
| SCHEMBL9273375 | 0.82 | ABCC9 (0.78) | ABCC9ABCB1 | |
| SCHEMBL9273379 | 0.82 | ABCC9 (0.78) | ABCC9ABCB1 | |
| SCHEMBL9532318 | 0.82 | ABCC9 (0.78) | ABCC9ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4575511-A | Anti-hypertensive chromanol derivatives | BEECHAM GROUP P.L.C. (GB) | 1986-03-11 | — | — | US | claimed |
| EP-0126367-B1 | Chroman and chromene derivatives | BEECHAM GROUP PLC (GB) | 1994-10-12 | — | — | EP | disclosed |
| US-4575511-A | Anti-hypertensive chromanol derivatives | BEECHAM GROUP P.L.C. (GB) | 1986-03-11 | — | — | US | disclosed |
| EP-0126367-A1 | Chroman and chromene derivatives | BEECHAM GROUP PLC (GB) | 1984-11-28 | — | — | EP | disclosed |