Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NPFFR1 | Q9GZQ6 | 1/20 | 0.42 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 2/20 | 0.42 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | YAP1 | P46937 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9354386 | 1.00 | SIGMAR1 (0.60) | SIGMAR1MAPK1KMT2AMEN1ALDH1A1 | |
| SCHEMBL9354851 | 0.90 | SIGMAR1 (0.56) | SIGMAR1MAPK1KMT2AMEN1ALDH1A1 | |
| SCHEMBL9354845 | 0.90 | SIGMAR1 (0.56) | SIGMAR1MAPK1KMT2AMEN1ALDH1A1 | |
| SCHEMBL7304469 | 0.84 | KDM4E (0.57) | MAPK1KMT2AMEN1YAP1GPR119 | |
| SCHEMBL7304465 | 0.84 | KDM4E (0.57) | MAPK1KMT2AMEN1YAP1GPR119 | |
| SCHEMBL14691386 | 0.81 | SIGMAR1 (0.66) | SIGMAR1KMT2AMEN1ALDH1A1TSHR | |
| SCHEMBL7381400 | 0.81 | KMT2A (0.51) | MAPK1KMT2AMEN1YAP1GPR119 | |
| SCHEMBL7307138 | 0.81 | KMT2A (0.51) | MAPK1KMT2AMEN1YAP1GPR119 | |
| SCHEMBL1222005 | 0.79 | SIGMAR1 (0.76) | SIGMAR1KMT2AMEN1ALDH1A1NPFFR1 | |
| SCHEMBL7983465 | 0.77 | SIGMAR1 (0.87) | SIGMAR1KMT2AMEN1TSHRNPFFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0300189-B1 | New amino acid derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1994-11-02 | — | — | EP | disclosed |
| US-5223489-A | Treatment of ypertension and heart failure | UJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-06-29 | — | — | US | disclosed |
| US-5142048-A | Enzyme inhibitor; carbamoyl group-containing acids | FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) | 1992-08-25 | — | — | US | disclosed |
| EP-0300189-A2 | New amino acid derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-01-25 | — | — | EP | disclosed |