Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.49 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.48 |
| ▸ | YAP1 | P46937 | 1/20 | 0.48 |
| ▸ | REN | P00797 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.46 |
| ▸ | STS | P08842 | 1/20 | 0.46 |
| ▸ | CKS1B | P61024 | 1/20 | 0.46 |
| ▸ | SKP1 | P63208 | 1/20 | 0.46 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7381400 | 1.00 | KMT2A (0.51) | KMT2AMAPK1MAPTNPSR1MEN1 | |
| SCHEMBL9326765 | 0.90 | KMT2A (0.55) | KMT2AMAPK1MAPTNPSR1MEN1 | |
| SCHEMBL7305910 | 0.90 | KMT2A (0.55) | KMT2AMAPK1MAPTNPSR1MEN1 | |
| SCHEMBL7304469 | 0.86 | KDM4E (0.57) | KMT2AMAPK1MEN1YAP1GPR119 | |
| SCHEMBL7304465 | 0.86 | KDM4E (0.57) | KMT2AMAPK1MEN1YAP1GPR119 | |
| SCHEMBL7305721 | 0.82 | KMT2A (0.52) | KMT2AMAPK1L3MBTL1KCNA3YAP1 | |
| SCHEMBL7305718 | 0.82 | KMT2A (0.52) | KMT2AMAPK1L3MBTL1KCNA3YAP1 | |
| SCHEMBL951538 | 0.81 | KMT2A (0.59) | KMT2AMAPK1MAPTNPSR1MEN1 | |
| SCHEMBL9354386 | 0.81 | SIGMAR1 (0.60) | KMT2AMAPK1MEN1YAP1GPR119 | |
| SCHEMBL7275022 | 0.81 | KMT2A (0.50) | KMT2AMAPK1MAPTNPSR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0417698-B1 | Amino acid derivatives having renin-inhibiting activity, process for their preparation, agents containing them, and their use | HOECHST AG (DE) | 1996-03-13 | — | — | EP | disclosed |
| US-5374731-A | Treatment of high blood pressure, congestive heart failure and viral disorders | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-12-20 | — | — | US | disclosed |
| EP-0417698-A2 | Amino acid derivatives having renin-inhibiting activity, process for their preparation, agents containing them, and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-03-20 | — | — | EP | disclosed |
| EP-0410278-A1 | Renin inhibiting aminooligohydroxy-derivatives | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-01-30 | — | — | EP | disclosed |