Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3135259 | 0.89 | IDO1 (0.40) | POLBKDM4EALDH1A1LMNASMN1; SMN2 | |
| Acetic Acid SCHEMBL2543982 | 0.80 | POLB (0.56) | POLBKDM4EALDH1A1LMNAHTT | |
| SCHEMBL1333179 | 0.74 | HTT (0.54) | POLBKDM4EALDH1A1SMN1; SMN2HTT | |
| SCHEMBL27939806 | 0.74 | AKR1C3 (0.53) | POLBKDM4EALDH1A1LMNAMAPT | |
| SCHEMBL6123415 | 0.72 | KDM4E (0.41) | POLBKDM4EALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL28274592 | 0.70 | LMNA (0.59) | KDM4EALDH1A1LMNAGLA | |
| SCHEMBL29841092 | 0.70 | CDC25A (0.57) | KDM4EALDH1A1LMNA | |
| SCHEMBL28120658 | 0.69 | KMT2A (0.41) | POLBKDM4EALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL28576274 | 0.69 | POLB (0.42) | POLBKDM4EALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL28068133 | 0.69 | PLK1 (0.57) | POLBKDM4ELMNACREBBPKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0625196-A1 | NEUROTROPHIC FACTOR | HOUSTON BIOTECHNOLOGY INCORPORATED (US) | 1994-11-23 | — | — | EP | disclosed |
| WO-1994012634-A1 | NEUROTROPHIC FACTOR | HOUSTON BIOTECHNOLOGY INCORPORATED (US) | 1994-06-09 | — | — | WO | disclosed |